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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 45 - 51 (7page)
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Rutin (3,3′,4′,5,7-pentahydroxyflavone-3-rhamnoglucoside) is a bioactive flavonoid from the plant kingdom. Rutin has been studied as potential anticancer agent due to its wide range of pharmacological properties including antioxidative, anti-inflammatory and anticancer. Autophagy is a conserved intracellular catabolic pathway to maintain cell homeostasis by formation of autophagosome. Processing of autophagy involves various molecules including ULK1 protein kinase complex, Beclin-1–Vps34 lipid kinase complex, ATG5, ATG12, and LC3 (light chain 3). Cargo-carried autophagosomes fuse with lysosomes resulting in autophagolysosome to eliminate vesicles and degrade cargo. However, the actions of rutin on autophagy are not clearly understood. In this study, we analyzed the effect of rutin on autophagy and inflammation in cancer cell lines. Interestingly, rutin induced autophagy in leukemia (THP-1), oral (CA9-22), and lung (A549) cell lines. TNF-α, key modulator of inflammation, was upregulated by inhibition of rutin-induced autophagy. Taken together, these data indicated that rutin induced autophagy and consequently suppressed TNF-α production.
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참고문헌 (28)
참고문헌 신청
Ligia C. Gomes / 2014 / Autophagy in Antimicrobial Immunity / Molecular Cell 54(2):224~233
Deretic V / 2012 / Autophagy: An Emerging Immunological Paradigm / J Immunol 189:15~20
V. Deretic / 2012 / Autophagy: An Emerging Immunological Paradigm / The Journal of Immunology 189(1):15~20
육재민 / 2013 / Crosstalk between Autophagy and Inflamma-somes / Molecules and Cells 36(5):393~399
Noboru Mizushima / 2008 / Autophagy fights disease through cellular self-digestion / Nature 451(7182):1069~1075
Deretic V / 2012 / Autophagy: An Emerging Immunological Paradigm / J Immunol 189:15~20
V. Deretic / 2012 / Autophagy: An Emerging Immunological Paradigm / The Journal of Immunology 189(1):15~20
육재민 / 2013 / Crosstalk between Autophagy and Inflamma-somes / Molecules and Cells 36(5):393~399
Noboru Mizushima / 2008 / Autophagy fights disease through cellular self-digestion / Nature 451(7182):1069~1075
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