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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 423 - 428 (6page)
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In vitro evolution is a powerful technique for the engineering of yeast strains to study cellular mechanisms associated with evolutionary adaptation; strains with desirable traits for industrial processes can also be generated. There are two distinct approaches to generate evolved strains in vitro: the sequential transfer of cells in the stationary phase into fresh medium or the continuous growth of cells in a chemostat bioreactor via the constant supply of fresh medium. In culture, evolutionary forces drive diverse adaptive mechanisms within the cell to overcome environmental or intracellular stressors. Especially, this engineering strategy has expanded to the field of human cell lines; the understanding of such adaptive mechanisms provides promising targets for the treatment of human genetic diseases and cancer. Therefore, this technology has the potential to generate numerous industrial, medical, and academic applications.
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참고문헌 (54)
참고문헌 신청
Borodina I / 2014 / Advances in metabolic engineering of yeast Saccharomyces cerevisiae for production of chemicals / Biotechnol. J 9:609~620
Padkina MV / 2018 / Prospects for the application of yeast display in biotechnology and cell biology(Review) / Appl. Biochem. Microbiol 54:337~351
Mans R / 2018 / Under pressure : evolutionary engineering of yeast strains for improved performance in fuels and chemicals production / Curr. Opin. Biotechnol 50:47~56
Portnoy VA / 2011 / Adaptive laboratory evolution-harnessing the power of biology for metabolic engineering / Curr. Opin. Biotechnol 22:590~594
Fulda S / 2010 / Cellular stress responses : cell survival and cell death / Int. J. Cell Biol 2010:214074
Padkina MV / 2018 / Prospects for the application of yeast display in biotechnology and cell biology(Review) / Appl. Biochem. Microbiol 54:337~351
Mans R / 2018 / Under pressure : evolutionary engineering of yeast strains for improved performance in fuels and chemicals production / Curr. Opin. Biotechnol 50:47~56
Portnoy VA / 2011 / Adaptive laboratory evolution-harnessing the power of biology for metabolic engineering / Curr. Opin. Biotechnol 22:590~594
Fulda S / 2010 / Cellular stress responses : cell survival and cell death / Int. J. Cell Biol 2010:214074
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