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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 292 - 300 (9page)
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Macrophages residing in various tissue types are unique in terms of their anatomical locations, ontogenies, developmental pathways, gene expression patterns, and immunological functions. Alveolar macrophages (AMs) reside in the alveolar lumen of the lungs and serve as the first line of defense for the respiratory tract. The immunological functions of AMs are implicated in the pathogenesis of various pulmonary diseases such as allergic asthma, chronic obstructive pulmonary disorder (COPD), pulmonary alveolar proteinosis (PAP), viral infection, and bacterial infection. Thus, the molecular mechanisms driving the development and function of AMs have been extensively investigated. In this review article, we discuss the roles of granulocytemacrophage colony-stimulating factor (GM-CSF) and transforming growth factor (TGF)-β in AM development, and provide an overview of the anti-inflammatory and proinflammatory functions of AMs in various contexts. Notably, we examine the relationships between the metabolic status of AMs and their development processes and functions. We hope that this review will provide new information and insight into AM development and function.
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참고문헌 (91)
참고문헌 신청
Antoniu, S. A. / 2020 / Pharmacotherapy options in pulmonary alveolar proteinosis / Expert Opin. Pharmacother 21:1359~1366
Bazewicz, C. G. / 2019 / Aldehyde dehydrogenase in regulatory T-cell development, immunity and cancer / Immunology 156:47~55
Belchamber, K. B. R. / 2017 / Macrophage dysfunction in respiratory disease / Results Probl. Cell Differ 62:299~313
Bhavsar, P. K. / 2010 / Corticosteroid suppression of lipoxin A4 and leukotriene B4 from alveolar macrophages in severe asthma / Respir. Res 11:71
Bissonnette, E. Y. / 2020 / Cross-talk between alveolar macrophages and lung epithelial cells is essential to maintain lung homeostasis / Front. Immunol 11:583042
Bazewicz, C. G. / 2019 / Aldehyde dehydrogenase in regulatory T-cell development, immunity and cancer / Immunology 156:47~55
Belchamber, K. B. R. / 2017 / Macrophage dysfunction in respiratory disease / Results Probl. Cell Differ 62:299~313
Bhavsar, P. K. / 2010 / Corticosteroid suppression of lipoxin A4 and leukotriene B4 from alveolar macrophages in severe asthma / Respir. Res 11:71
Bissonnette, E. Y. / 2020 / Cross-talk between alveolar macrophages and lung epithelial cells is essential to maintain lung homeostasis / Front. Immunol 11:583042
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