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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.1
- 수록면
- 1 - 12 (12page)
- DOI
- 10.1016/j.mocell.2024.100140
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초록· 키워드
오류제보하기
The human lung alveolus is a well-structured and coordinated pulmonary unit, allowing them to perform diverse functions.
While there has been significant progress in understanding the molecular and cellular mechanisms behind human alveolardevelopment and pulmonary diseases, the underlying mechanisms of alveolar differentiation and disease development arestill unclear, mainly due to the limited availability of human tissues and a lack of proper in vitro lung model systemsmimicking human lung physiology. In this review, we summarize recent advances in creating human lung organoid modelsthat mimic alveolar epithelial cell types. Moreover, we discuss how lung alveolar organoid systems are being applied torecent cutting-edge research on lung development, regeneration, and diseases.
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