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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.8
- 수록면
- 541 - 548 (8page)
- DOI
- 10.14348/molcells.2021.0078
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초록· 키워드
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The discovery of human pluripotent stem cells (PSCs) at the turn of the century opened the door to a new generation of regenerative medicine research. Among PSCs, the donors available for induced pluripotent stem cells (iPSCs) are greatest, providing a potentially universal cell source for all types of cell therapies including cancer immunotherapies using natural killer (NK cells). Unlike primary NK cells, those prepared from iPSCs can be prepared with a homogeneous quality and are easily modified to exert a desired response to tumor cells. There already exist several protocols to genetically modify and differentiate iPSCs into NK cells, and each has its own advantages with regards to immunotherapies. In this short review, we detail the benefits of using iPSCs in NK cell immunotherapies and discuss the challenges that must be overcome before this approach becomes mainstream in the clinic.
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참고문헌 (53)
참고문헌 신청
Bachanova, V. / 2014 / NK cells in therapy of cancer / Crit. Rev. Oncog 19:133~141
Cichocki, F. / 2020 / iPSCderived NK cells maintain high cytotoxicity and enhance in vivo tumor control in concert with T cells and anti-PD-1 therapy / Sci. Transl. Med 12:eaaz5618
Delconte, R. B. / 2016 / CIS is a potent checkpoint in NK cell-mediated tumor immunity / Nat. Immunol 17:816~824
Dianat-Moghadam, H. / 2018 / Natural killer cell-based immunotherapy: from transplantation toward targeting cancer stem cells / J. Cell. Physiol 234:259~273
Felices, M. / 2018 / Continuous treatment with IL-15 exhausts human NK cells via a metabolic defect / JCI Insight 3:e96219
Cichocki, F. / 2020 / iPSCderived NK cells maintain high cytotoxicity and enhance in vivo tumor control in concert with T cells and anti-PD-1 therapy / Sci. Transl. Med 12:eaaz5618
Delconte, R. B. / 2016 / CIS is a potent checkpoint in NK cell-mediated tumor immunity / Nat. Immunol 17:816~824
Dianat-Moghadam, H. / 2018 / Natural killer cell-based immunotherapy: from transplantation toward targeting cancer stem cells / J. Cell. Physiol 234:259~273
Felices, M. / 2018 / Continuous treatment with IL-15 exhausts human NK cells via a metabolic defect / JCI Insight 3:e96219
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