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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 591 - 599 (9page)
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Complex cell-to-cell communication underlies the basic processes essential for homeostasis in the given tissue architecture. Obtaining quantitative gene-expression of cells in their native context has significantly advanced through single-cell RNA sequencing technologies along with mechanical and enzymatic tissue manipulation. This approach, however, is largely reliant on the physical dissociation of individual cells from the tissue, thus, resulting in a library with unaccounted positional information. To overcome this, positional information can be obtained by integrating imaging and positional barcoding. Collectively, spatial transcriptomics strategies provide tissue architecture-dependent as well as position-dependent cellular functions. This review discusses the current technologies for spatial transcriptomics ranging from the methods combining mechanical dissociation and single-cell RNA sequencing to computational spatial re-mapping.
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등록된 정보가 없습니다.
참고문헌 (64)
참고문헌 신청
Achim, K. / 2015 / High-throughput spatial mapping of single-cell RNA-seq data to tissue of origin / Nat. Biotechnol 33:503~509
Asp, M. / 2019 / A spatiotemporal organ-wide gene expression and cell atlas of the developing human heart / Cell 179:1647~1660.e19
Avital, G. / 2017 / scDual-Seq : mapping the gene regulatory program of Salmonella infection by host and pathogen single-cell RNA-sequencing / Genome Biol 18:200
Boisset, J. C. / 2018 / Mapping the physical network of cellular interactions / Nat. Methods 15:547~553
Browaeys, R. / 2020 / NicheNet : modeling intercellular communication by linking ligands to target genes / Nat. Methods 17:159~162
Asp, M. / 2019 / A spatiotemporal organ-wide gene expression and cell atlas of the developing human heart / Cell 179:1647~1660.e19
Avital, G. / 2017 / scDual-Seq : mapping the gene regulatory program of Salmonella infection by host and pathogen single-cell RNA-sequencing / Genome Biol 18:200
Boisset, J. C. / 2018 / Mapping the physical network of cellular interactions / Nat. Methods 15:547~553
Browaeys, R. / 2020 / NicheNet : modeling intercellular communication by linking ligands to target genes / Nat. Methods 17:159~162
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