지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 136 - 145 (10page)
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초록· 키워드
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Senescent cells that gradually accumulate during aging are one of the leading causes of aging. While senolytics can improve aging in humans as well as mice by specifically eliminating senescent cells, the effect of the senolytics varies in different cell types, suggesting variations in senescence. Various factors can induce cellular senescence, and the rate of accumulation of senescent cells differ depending on the organ. In addition, since the heterogeneity is due to the spatiotemporal context of senescent cells, in vivo studies are needed to increase the understanding of senescent cells. Since current methods are often unable to distinguish senescent cells from other cells, efforts are being made to find markers commonly expressed in senescent cells using bulk RNA-sequencing. Moreover, single-cell RNA (scRNA) sequencing, which analyzes the transcripts of each cell, has been utilized to understand the in vivo characteristics of the rare senescent cells. Recently, transcriptomic cell atlases for each organ using this technology have been published in various species. Novel senescent cells that do not express previously established marker genes have been discovered in some organs. However, there is still insufficient information on senescent cells due to the limited throughput of the scRNA sequencing technology. Therefore, it is necessary to improve the throughput of the scRNA sequencing technology or develop a way to enrich the rare senescent cells. The in vivo senescent cell atlas that is established using rapidly developing single-cell technologies will contribute to the precise rejuvenation by specifically removing senescent cells in each tissue and individual.
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참고문헌 (71)
참고문헌 신청
Acosta, J. C. / 2008 / Chemokine signaling via the CXCR2 receptor reinforces senescence / Cell 133:1006~1018
Almanzar, N. / 2020 / A single-cell transcriptomic atlas characterizes ageing tissues in the mouse / Nature 583:590~595
Amor, C. / 2020 / Senolytic CAR T cells reverse senescence-associated pathologies / Nature 583:127~132
Ashapkin, V. V. / 2017 / Aging as an epigenetic phenomenon / Curr. Genomics 18:385~407
Baar, M. P. / 2017 / Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging / Cell 169:132~147
Almanzar, N. / 2020 / A single-cell transcriptomic atlas characterizes ageing tissues in the mouse / Nature 583:590~595
Amor, C. / 2020 / Senolytic CAR T cells reverse senescence-associated pathologies / Nature 583:127~132
Ashapkin, V. V. / 2017 / Aging as an epigenetic phenomenon / Curr. Genomics 18:385~407
Baar, M. P. / 2017 / Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging / Cell 169:132~147
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