지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 527 - 532 (6page)
이용수
초록· 키워드
오류제보하기
We recently reported that N-adamantyl-4-methylthiazol-2-amine (KHG26693) attenuates glutamate-induced oxidative stress and inflammation in the brain. In this study, we investigated KHG 26693 as a therapeutic agent against glutamate-induced autophagic death of cortical neurons. Treatment with KHG26693 alone did not affect the viability of cultured cortical neurons but was protective against glutamate-induced cytotoxicity in a concentration-dependent manner. KHG26693 attenuated the glutamate-induced increase in protein levels of LC3, beclin-1, and p62. Whereas glutamate decreased the phosphorylation of PI3K, Akt, and mTOR, these levels were restored by treatment with KHG26693. These results suggest that KHG26693 inhibits glutamate-induced autophagy by regulating PI3K/Akt/mTOR signaling. Finally, KHG26693 treatment also attenuated glutamateinduced increases in reactive oxygen species, glutathione, glutathione peroxidase, and superoxide dismutase levels in cortical neurons, indicating that KHG26693 also protects cortical neurons against glutamate-induced autophagy by regulating the reactive oxygen species scavenging system.
목차
등록된 정보가 없습니다.
참고문헌 (34)
참고문헌 신청
Blandini F / 1996 / The role of glutamate in the pathophysiology of Parkinson’s disease / Funct Neurol 11:3~15
Olney JW / 2003 / Excitotoxicity, apoptosis and neuropsychiatric disorders / Curr Opin Pharmacol 3:101~109
Kalia LV / 2008 / NMDA receptors in clinical neurology : excitatory times ahead / Lancet Neurol 7:742~755
Patel M / 1996 / Requirement for superoxide in excitotoxic cell death / Neuron 16:345~355
Halliwell B / 2006 / Oxidative stress and neurodegeneration:where are we now? / J Neurochem 97:1634~1658
Olney JW / 2003 / Excitotoxicity, apoptosis and neuropsychiatric disorders / Curr Opin Pharmacol 3:101~109
Kalia LV / 2008 / NMDA receptors in clinical neurology : excitatory times ahead / Lancet Neurol 7:742~755
Patel M / 1996 / Requirement for superoxide in excitotoxic cell death / Neuron 16:345~355
Halliwell B / 2006 / Oxidative stress and neurodegeneration:where are we now? / J Neurochem 97:1634~1658
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Protective effects of N,4,5-trimethylthiazol-2-amine hydrochloride on hypoxia-induced -amyloid production in SH-SY5Y cells
BMB Reports
2019 .01
-
Protective effect of 3-(naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride on hypoxia-induced toxicity by suppressing microglial activation in BV-2 cells
BMB Reports
2016 .01
-
Anti-inflammatory effects of N-cyclooctyl-5-methylthiazol-2-amine hydrobromide on lipopolysaccharide-induced inflammatory response through attenuation of NLRP3 activation in microglial cells
BMB Reports
2021 .11
-
KHG-Aclair: Knowledge Hypergraph-Based Attention with Contrastive Learning for Recommendations
Journal of Computing Science and Engineering
2024 .09
-
Biogenic Selenium Nanoparticle Induces Apoptosis and Autophagy in Human Gastric Cancer Cells by Suppressing the PI3K/AKT/mTOR Signaling Pathway
한국생물공학회 학술대회
2022 .04
-
심층 신경망 압축을 위한 중복뉴런 제거 기법
대한전자공학회 학술대회
2017 .11
-
Brain somatic mutations in MTOR leading to focal cortical dysplasia
BMB Reports
2016 .01
-
뉴런 커버리지 변화에 따른 학습 데이터의 모델 영향력 평가
전자공학회논문지
2022 .05
-
Neuron-Aware Training for IF neurons with non-linearity in Spiking Neural Networks
대한전자공학회 학술대회
2022 .06
-
Volatile Memristor-Based Artificial Spiking Neurons for Bioinspired Computing
전기전자재료학회논문지
2022 .07
-
Electrophysiological Properties of Hypothalamus Neurons
한국생물공학회 학술대회
2021 .10
-
Regulation of autophagy by perilysosomal calcium: a new player in β-cell lipotoxicity
Experimental and Molecular Medicine
2024 .02
-
Analysis of energy consumption of integrate-and-fire neuron circuit
대한전자공학회 학술대회
2022 .06
-
Anti-inflammatory and anti-oxidative effects of 3-(naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride on β-amyloid-induced microglial activation
BMB Reports
2017 .01
-
Review of Analog Neuron Devices for Hardware-based Spiking Neural Networks
JOURNAL OF SEMICONDUCTOR TECHNOLOGY AND SCIENCE
2022 .04
-
Rapamycin-resistant and torin-sensitive mTOR signaling promotes the survival and proliferation of leukemic cells
BMB Reports
2016 .01
-
Design of a Neural Chip for Classifying Iris Flowers based on CMOS Analog Neurons
센서학회지
2019 .01
-
Integration of Neuronal Excitatory and Inhibitory Functions in a Neuron Circuit Using Positive Feedback Field Effect Transistor
JOURNAL OF SEMICONDUCTOR TECHNOLOGY AND SCIENCE
2025 .04
-
저 전력 동작을 위한 뉴런 모방 회로의 파라미터 최적화
대한전자공학회 학술대회
2016 .06
-
Chemical Inhibition of Autophagy : Examining its Potential to Increase the Specific Productivity of Recombinant CHO Cell Lines
한국생물공학회 학술대회
2016 .04
이 논문의 저자 정보
최근 본 자료
댓글(0)
0