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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 634 - 639 (6page)
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초록· 키워드
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We aimed to assess the anti-inflammatory and antioxidative properties of KHG26792, a novel azetidine derivative, in amyloid β (Aβ)-treated primary microglial cells. KHG26792 attenuated the Aβ-induced production of inflammatory mediators such as IL-6, IL-1β, TNF-α, and nitric oxide. The levels of protein oxidation, lipid peroxidation, ROS, and NADHP oxidase enhanced by Aβ were also downregulated by KHG26792 treatment. The effects of KHG26792 against the Aβ-induced increases in inflammatory cytokine levels and oxidative stress were achieved by increasing the phosphorylation of Akt/ GSK-3β signaling and by decreasing the Aβ-induced translocation of NF-κB. Our results provide novel insights into the use of KHG26792 as a potential agent against Aβ toxicity, including its role in the reduction of inflammation and oxidative stress. Nevertheless, further investigations of cellular signaling are required to clarify the in vivo effects of KHG26792 against Aβ-induced toxicity.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Bach JP / 2011 / The role of CNI-1493 in the function of primary microglia with respect to amyloid-beta / J Alzheimers Dis 26 : 69 ~ 80
Butterfield DA / 2002 / Lipid peroxidation and protein oxidation in Alzheimer’s disease brain: potential causes and consequences involving amyloid beta-peptide associated f
Cerpa W / 2008 / Structure?function implications in Alzheimer’s disease: effect of Abeta oligomers at central synapses / Curr Alzheimer Res 5 : 233 ~ 243
Chen JX / 2010 / Role of mitochondrial amyloid-beta in Alzheimer’s disease / J Alzheimers Dis 20 : S569 ~ S578
Dalla Y / 2009 / Potential of ezetimibe in memory deficits associated with dementia of Alzheimer’s type in mice / Indian J Pharmacol 41 : 262 ~ 267
Butterfield DA / 2002 / Lipid peroxidation and protein oxidation in Alzheimer’s disease brain: potential causes and consequences involving amyloid beta-peptide associated f
Cerpa W / 2008 / Structure?function implications in Alzheimer’s disease: effect of Abeta oligomers at central synapses / Curr Alzheimer Res 5 : 233 ~ 243
Chen JX / 2010 / Role of mitochondrial amyloid-beta in Alzheimer’s disease / J Alzheimers Dis 20 : S569 ~ S578
Dalla Y / 2009 / Potential of ezetimibe in memory deficits associated with dementia of Alzheimer’s type in mice / Indian J Pharmacol 41 : 262 ~ 267
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