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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 385 - 390 (6page)
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Inflammatory Bowel Disease is caused by an acute or chronic dysfunction of the mucosal inflammatory system in the intestinal tract. In line with the results of our previous study, wherein we found that the PKC?-LSD1-NF-?B signaling plays a critical role in the prolonged activation of the inflammatory response, we aimed to investigate the effect of signaling on colitis in the present study. Lsd1 S112A knock-in (Lsd1SA/SA) mice, harboring a deficiency in phosphorylation by PKC?, exhibited less severe colitis symptoms and a relatively intact colonic epithelial lining in dextran sulfate sodium (DSS)- induced colitis models. Additionally, a reduction in pro-inflammatory gene expression and immune cell recruitment into damaged colon tissues in Lsd1SA/SA mice was observed upon DSS administration. Furthermore, LSD1 inhibition alleviated colitis symptoms and reduced colonic inflammatory responses. Both LSD1 phosphorylation and its activity jointly play a role in the progression of DSS-induced colitis. Therefore, the inhibition of LSD1 activity could potentially protect against the colonic inflammatory response.
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참고문헌 (36)
참고문헌 신청
Podolsky DK / 2002 / Inflammatory bowel disease / N Engl J Med 347:417~429
Kostić M / 2016 / Inflammatory bowel diseases(crohn’s disease and ulcerative colitis) : cost of treatment in serbia and the implications / Appl Health Econ Health Policy 15:85~93
강인성 / 2019 / Interferon-γ-mediated secretion of tryptophanyl-tRNA synthetases has a role in protection of human umbilical cord blood-derived mesenchymal stem cells against experimental colitis / BMB Reports 52(5):318~323
Yu YR / 2017 / Clinical presentation of crohn’s, ulcerative colitis, and indeterminate colitis : Symptoms, extraintestinal manifestations, and disease phenotypes / Semin Pediatr Surg 26:349~355
Oliva-Hemker M / 2006 / Indeterminate colitis : A significant subgroup of pediatric IBD / Inflamm Bowel Dis 12:258~262
Kostić M / 2016 / Inflammatory bowel diseases(crohn’s disease and ulcerative colitis) : cost of treatment in serbia and the implications / Appl Health Econ Health Policy 15:85~93
강인성 / 2019 / Interferon-γ-mediated secretion of tryptophanyl-tRNA synthetases has a role in protection of human umbilical cord blood-derived mesenchymal stem cells against experimental colitis / BMB Reports 52(5):318~323
Yu YR / 2017 / Clinical presentation of crohn’s, ulcerative colitis, and indeterminate colitis : Symptoms, extraintestinal manifestations, and disease phenotypes / Semin Pediatr Surg 26:349~355
Oliva-Hemker M / 2006 / Indeterminate colitis : A significant subgroup of pediatric IBD / Inflamm Bowel Dis 12:258~262
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