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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.6
- 수록면
- 71 - 83 (13page)
- DOI
- https://doi.org/10.14397/jals.2017.51.3.71
이용수
초록· 키워드
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Treatment of dextran sodium sulfate(DSS) on HeLa cells results to an enhanced susceptibilityto Brucella(B.) abortus infection. An increase in the adherence, invasion and intracellularreplication of B. abortus was observed in DSS-treated cells. Furthermore, a marked elevation inthe intensity of F-actin fluorescence was also observed in DSS-treated cells compared withuntreated B. abortus-infected cells. An upregulation of phagocytic signaling proteins by Westernblot analysis demonstrated an apparent activation of ERK, p38α and JNK phosphorylationlevels in B. abortus-infected DSS-treated cells compared with the control. Colocalization withLAMP-1 proteins was attenuated in DSS-treated cells upon intracellular trafficking of thepathogen compared with control cells. The results of this study demonstrated consistency withother pathogens. The uptake and intracellular replication of B. abortus is hypothesized to bestimulated by various dextran receptors such as C-type lectins that are involved in phagocytosiswhich can either be direct phagocytic receptors, modulators of the expression of other receptorsor as opsonins leading to an enhanced internalization of B. abortus. The complexity of theseinteractions thus would warrant further investigation into the role of DSS in the pathogenesis ofbrucellosis. In summary, we conclude that DSS enhanced adhesion, phagocytosis and intracellularreplication of B. abortus in epithelial cells which could lead to suppression of the innateimmune system in chronic Brucella infection.
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참고문헌 (28)
참고문헌 신청
Castaneda-Roldan E / 2004 / Adherence of Brucella to human epithelial cells and macrophages is mediated by sialic acid residues / Cell. Microbiol 6:435~455
Chakravortty D / 2003 / Inducible nitric oxide synthase and control of intracellular bacterial pathogens / Microbes Infect 5:621~627
Chao Y / 2012 / Role of carbohydrate receptors in the macrophage uptake of dextran-coated iron oxide nanoparticles / Adv. Exp. Med. Biol 733:115~123
Dramsi S / 1998 / Intracellular pathogens and the actin cytoskeleton / Ann. Rev. Dev. Biol 14:137~166
Gomez G / 2013 / Host-Brucella interactions and the Brucella genome as tools for subunit antigen discovery and immunization against brucellosis / Front. Cell. Infect. Microbiol 3:1~15
Chakravortty D / 2003 / Inducible nitric oxide synthase and control of intracellular bacterial pathogens / Microbes Infect 5:621~627
Chao Y / 2012 / Role of carbohydrate receptors in the macrophage uptake of dextran-coated iron oxide nanoparticles / Adv. Exp. Med. Biol 733:115~123
Dramsi S / 1998 / Intracellular pathogens and the actin cytoskeleton / Ann. Rev. Dev. Biol 14:137~166
Gomez G / 2013 / Host-Brucella interactions and the Brucella genome as tools for subunit antigen discovery and immunization against brucellosis / Front. Cell. Infect. Microbiol 3:1~15
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