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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 522 - 527 (6page)
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Lysine-specific demethylase 1 (LSD1) is an epigenetic regulator that modulates the chromatin status, contributing to gene activation or repression. The post-translational modification of LSD1 is critical for the regulation of many of its biological processes. Phosphorylation of serine 112 of LSD1 by protein kinase C alpha (PKCα) is crucial for regulating inflammation, but its physiological significance is not fully understood. This study aimed to investigate the role of Lsd1-S112A, a phosphorylation defective mutant, in the cigarette smoke extract/LPS-induced chronic obstructive pulmonary disease (COPD) model using Lsd1SA/SA mice and to explore the potential mechanism underpinning the development of COPD. We found that Lsd1SA/SA mice exhibited increased susceptibility to CSE/LPS-induced COPD, including high inflammatory cell influx into the bronchoalveolar lavage fluid and airspace enlargement. Additionally, the high gene expression associated with the inflammatory response and oxidative stress was observed in cells and mice containing Lsd1-S112A. Similar results were obtained from the mouse embryonic fibroblasts exposed to a PKCα inhibitor, Go6976. Thus, the lack of LSD1 phosphorylation exacerbates CSE/LPS-induced COPD by elevating inflammation and oxidative stress.
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참고문헌 (30)
참고문헌 신청
Corlateanu A / 2020 / Chronic obstructive pulmonary disease and phenotypes : a state-ofthe-art / Pulmonology 26:95~100
Sundar IK / 2016 / Gene expression profiling of epigenetic chromatin modification enzymes and histone marks by cigarette smoke : implications for COPD and lung cancer / Am J Physiol Lung Cell Mol Physiol 311:L1245~L1258
Ito K / 2005 / Decreased histone deacetylase activity in chronic obstructive pulmonary disease / N Engl J Med 352:1967~1976
Nakamaru Y / 2009 / A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9 / FASEB J 23:2810~2819
Sundar IK / 2014 / Cigarette smoke induces distinct histone modifications in lung cells : Implications for the pathogenesis of COPD and lung cancer / J Proteome Res 13:982~996
Sundar IK / 2016 / Gene expression profiling of epigenetic chromatin modification enzymes and histone marks by cigarette smoke : implications for COPD and lung cancer / Am J Physiol Lung Cell Mol Physiol 311:L1245~L1258
Ito K / 2005 / Decreased histone deacetylase activity in chronic obstructive pulmonary disease / N Engl J Med 352:1967~1976
Nakamaru Y / 2009 / A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9 / FASEB J 23:2810~2819
Sundar IK / 2014 / Cigarette smoke induces distinct histone modifications in lung cells : Implications for the pathogenesis of COPD and lung cancer / J Proteome Res 13:982~996
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