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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.7
- 수록면
- 202 - 202 (1page)
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Kruppel-Like Factor 10 (KLF10), an important transcription factor for hepatic glucose and lipid metabolism thought to be linked with liver injury and repair. However, it is not clear if KLF10 plays a role in reducing injury or activating repair in TAA-induced liver injury. Also, the molecular mechanism of KLF10 in the liver injury model is largely unknown. Here, we demonstrated that TAA-induced liver toxicity was significantly increased in KLF10 knockout mice. Strikingly, 70% of KLF10-/- mice die within 48 hours after TAA 300 mg/kg/BW treatment that generally known as a safe dose to induce liver injury without notable lethality. Histological analysis of TAA-treated liver of KLF10 knockout mice revealed a significant increase of TUNNEL positive shrunk hepatic nuclei, characteristics of pyknosis, inflamma ... 전체 초록 보기
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