지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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The hemolymph of Korean rhinoceros Allomyrina dichotoma consists of blood and lymph in which various kinds of proteins function physiologically. We have previously demonstrated that A. dichotoma hemolymph has the potential to treatment and prevent diabetes through activating transcription factor 3-gene (ATF3) regulation. In this study, we investigate the expression of Kruppel-like factor 4 (KLF4) in A. dichotoma hemolymph-treated INS-1 pancreatic β-cells. The new findings show that A. dichotoma hemolymph, which upregulates KLF4 gene expression in a dose-dependent and timedependent manner. In addition, hemolymph combine with mild endoplasmic reticulum (ER) stress, which also differentially regulates KLF4 gene expression. These results may provide insights to KLF4 gene-related disease therapies through KLF4 gene regulation.
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참고문헌 (26)
참고문헌 신청
Ahn MY / 2014 / Antiinflammatory effect of glycosaminoglycan derived from Gryllus bimaculatus on adjuvant-treated chronic arthritis rat model / J Toxicol Environ Health Part A 7:1332~1345
Baiceanu A / 2016 / Endoplasmic reticulum proteostasis in hepatic steatosis / Nat Rev Endocrinol 124:710~722
Blow F / 2019 / The hemolymph microbiome of insects / J Insect Physiol 115:33~39
최용화 / 2006 / 장수풍뎅이 유충 추출물이 사염화탄소에 의한 마우스의 간 손상에 미치는 영향 / 한국식품영양과학회지 35(10):1349~1355
정미연 / 2014 / Anti‐obesity effect of Allomyrina dichotoma (Arthropoda: Insecta) larvae ethanol extract on 3T3‐L1 adipocyte differentiation / Entomological Research 44(1):9~16
Baiceanu A / 2016 / Endoplasmic reticulum proteostasis in hepatic steatosis / Nat Rev Endocrinol 124:710~722
Blow F / 2019 / The hemolymph microbiome of insects / J Insect Physiol 115:33~39
최용화 / 2006 / 장수풍뎅이 유충 추출물이 사염화탄소에 의한 마우스의 간 손상에 미치는 영향 / 한국식품영양과학회지 35(10):1349~1355
정미연 / 2014 / Anti‐obesity effect of Allomyrina dichotoma (Arthropoda: Insecta) larvae ethanol extract on 3T3‐L1 adipocyte differentiation / Entomological Research 44(1):9~16
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UCI(KEPA) : I410-ECN-0101-2020-510-000511938