Ginseng saponin enriched in Rh1 and Rg2 ameliorates non-alcoholic fatty liver disease by inhibiting inflammasome activation

Feng Wang; JeongSu Park; Hwan Ma; Gyu-rim Lee; Yeojin Lee; Yuanqiang Ma; Yoon-Seok Roh

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자료유형: 학술대회자료

저자정보: Feng Wang (Chungbuk National University) JeongSu Park (Chungbuk National University) Hwan Ma (Chungbuk National University) Gyu-rim Lee (Chungbuk National University) Yeojin Lee (Chungbuk National University) Yuanqiang Ma (Chungbuk National University) Yoon-Seok Roh (Chungbuk National University)

저널정보: 한국실험동물학회 한국실험동물학회 학술발표대회 논문집 2021년 한국실험동물학회 국제학술대회 [초록집]

발행연도: 2021.7

수록면: 189 - 189 (1page)

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NAFLD is becoming one of the most common chronic liver diseases in the world. One of the features of NAFLD is fat accumulation in the liver, which increased hepatic steatosis, fibrosis, and inflammation. Several different saponins have been identified as the major pharmacologically active ingredients isolated from Panax notoginseng. The most important compounds of saponins are ginsenosides. However, the ginsenoside-specific molecular mechanism of the Saponin has not been known in NAFLD. The mouse NAFLD model was established by feeding with Fast food diet for 16 weeks and treated with Saponin (50 or 150mg / kg) for the last 9 weeks. Saponin extract treatment reversed the FFD-induced elevation in the expression levels of lipogenesis-related genes, including fatty acid synthase (FASN) and MLX-interacting protein-like (MLXIPL), to the levels in NCD-fed mice. Surprisingly, the weight and size of the liver was significantly attenuated in the low- or high-dose saponin extract administered groups, compare ... 전체 초록 보기

#NAFLD #Ginsenosides #Inflammasome #Mitophagy

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