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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.7
- 수록면
- 179 - 179 (1page)
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Pseudolarix kaempferi is a potential therapeutic and cytotoxic agent against cancer. However, the precise molecular mechanism of its cytotoxic effects has not yet been fully elucidated. Here, we unravel the mechanism by which the ethanol extract of P. kaempferi (EEPK) leads to cytotoxicity mediated by apoptosis in mucoepidermoid carcinoma (MEC) originating from salivary glands. We investigated the underlying mechanism of the anticancer efficacy of EEPK in human MEC in vitro by assessing mitochondrial dysfunction, mRNA levels, and morphological changes in the nuclei of apoptotic cells as well as by using cytotoxicity assay, flow cytometric analysis, and western blot. EEPK inhibited the growth of two human MEC cells. This was related to the induction of caspase-mediated apoptosis that occurred due to mitochondrial membrane depolarization. EEPK decreased myeloid cell leukemia-1 (Mcl-1) in both cells compared with the vehicle ... 전체 초록 보기
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