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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.7
- 수록면
- 95 - 95 (1page)
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Despite multiple associations between the microbiota and immune diseases, its role in autoimmunity is poorly understood. Several mechanisms have recently been uncovered including gut commensal translocation (Vieira et al, Science 2018) and commensal ortholog cross-reactivity with autoantigens (Greiling et al, Sci Transl Med 2018). In this talk, I will cover diet-microbiota interactions in inflammatory models of excessive toll-like receptor (TLR7) signaling. Specifically, I will show how a resistant starch diet enriches short-chain fatty acid (SCFA)-producing bacteria (including Clostridiales) that in turn suppress a translocating pathobiont, Lactobacillus reuteri. L. reuteri, but not L. johnsonii, exacerbates the plasmacytoid dendritic cell (pDC)/type I interferon (IFN) axis in TLR7-overexpressing mice (Zegarra Ruiz et al, Cell Hos^_@span style=color:#999999 ^_# ... ^_@/span^_#^_@a href=javascript:; onclick=onClickReadNode('NODE10617876');fn_statistics('Z354','null','null'); style='color:#999999;font-size:14px;text-decoration:underline;' ^_#전체 초록 보기^_@/a^_#
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