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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 저널정보
- 한국수산과학회 양식분과 한국수산과학회 양식분과 학술대회 2021 Conference on the Future Technology of Fisheries Science [3개 분과 공동개최]
- 발행연도
- 2021.4
- 수록면
- 350 - 350 (1page)
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초록· 키워드
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Antimicrobial peptides (AMPs) are promising therapeutic agents for treating microbial infections and removing biofilms formed by pathogenic bacteria. Acinetobacter baumannii is a Gram negative, highly pathogenic, nosocomial opportunistic multi-drug resistance (MDR) bacterium. It forms biofilms, which contributes many persistent and chronic bacterial infections in hospital environments and on medical devices. Majority of antibiotics have failed to control MDR A. baumannii due to low antibiotic penetration capacity through the thick biofilm and have reduced antibiotic susceptibility. In this study, we used Octominin, a newly designed synthetic AMP (23 aa) derived from defense protein 3 of Octopus minor for testing antibacterial and antibiofilm activity against A. baumannii. In vitro broth microdilution results showed Octominin had efficient antibacterial activity for A. baumannii with minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of 5 µg/mL and 10 µg/mL, respectively. Moreover, time-kill kinetics results showed A. ... 전체 초록 보기
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UCI(KEPA) : I410-ECN-0101-2021-529-001946376