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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.8
- 수록면
- 166 - 166 (1page)
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Aim(s): This study aims to identify biomarkers for age-related cognitive decline by examining the DNA methylation differences between normal cognitive aging (NCA) and successful cognitive aging (SCA) groups among community-dwelling older adults.
Method(s): Demographic and neuropsychological data and peripheral blood samples were obtained from the Korean Frailty and Aging Cohort Study (KFACS). The subjects were grouped into two categories―NCA and SCA. The subjects whose cognitive function test scores lay above the 50th percentile of Korean older adults score were grouped as SCA. The DNA methylation microarray using Illumina Infinium Methylation EPIC BeadChip was performed to identify the differentially methylated genes as potential DNA methylation-based blood biomarkers. The differences between NCA and SCA groups were tested using the X2 test, t-test, and Mann-whitey U test using SPSS software 25.0.
Result(s): Fourteen par ... 전체 초록 보기
Method(s): Demographic and neuropsychological data and peripheral blood samples were obtained from the Korean Frailty and Aging Cohort Study (KFACS). The subjects were grouped into two categories―NCA and SCA. The subjects whose cognitive function test scores lay above the 50th percentile of Korean older adults score were grouped as SCA. The DNA methylation microarray using Illumina Infinium Methylation EPIC BeadChip was performed to identify the differentially methylated genes as potential DNA methylation-based blood biomarkers. The differences between NCA and SCA groups were tested using the X2 test, t-test, and Mann-whitey U test using SPSS software 25.0.
Result(s): Fourteen par ... 전체 초록 보기
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UCI(KEPA) : I410-ECN-0101-2021-512-001928259