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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.5
- 수록면
- 199 - 199 (1page)
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Purpose
An accurate gene signature is useful in assisting physicians to make a more accurate evaluation in clinical practice. The aim of this study was to de-velop and validate a prognostic DNA methylation signature model for prediction of recurrence in colorectal cancer patients.
Method
We used genomic data of colorectal cancer (CRC) patients (n=236) in stage I to III from The Cancer Genome Atlas (TCGA) and selected patients who have both DNA methylation array and mRNA-seq data. We identified differentially expressed mRNAs between recurrence and non-recurrence groups using R package DESeq2. Then, we found DNA methylation that had an inverse relationship with mRNAs. Using Cox regression analyses, a DNA methylation signature was established and used for predicting the disease-free survival (DFS) in training and testing cohorts. Receiver operat-ing characteristic (ROC) curve was used to validate the prognosis performance of our model through calculati^_@span style=color:#999999 ^_# ... ^_@/span^_#^_@a href=javascript:; onclick=onClickReadNode('NODE10577864');fn_statistics('Z354','null','null'); style='color:#999999;font-size:14px;text-decoration:underline;' ^_#전체 초록 보기^_@/a^_#
An accurate gene signature is useful in assisting physicians to make a more accurate evaluation in clinical practice. The aim of this study was to de-velop and validate a prognostic DNA methylation signature model for prediction of recurrence in colorectal cancer patients.
Method
We used genomic data of colorectal cancer (CRC) patients (n=236) in stage I to III from The Cancer Genome Atlas (TCGA) and selected patients who have both DNA methylation array and mRNA-seq data. We identified differentially expressed mRNAs between recurrence and non-recurrence groups using R package DESeq2. Then, we found DNA methylation that had an inverse relationship with mRNAs. Using Cox regression analyses, a DNA methylation signature was established and used for predicting the disease-free survival (DFS) in training and testing cohorts. Receiver operat-ing characteristic (ROC) curve was used to validate the prognosis performance of our model through calculati^_@span style=color:#999999 ^_# ... ^_@/span^_#^_@a href=javascript:; onclick=onClickReadNode('NODE10577864');fn_statistics('Z354','null','null'); style='color:#999999;font-size:14px;text-decoration:underline;' ^_#전체 초록 보기^_@/a^_#
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