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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.5
- 수록면
- 65 - 65 (1page)
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Background : Holigarna longifolia (Roxb.) is commonly used in the traditional medicine to treat a variety of painful conditions like eye irritation, inflammation, arthritis, skin diseases, cuts, and wounds. The present study was undertaken to investigate the antinociceptive and anti-inflammatory activities of methanol extract of H. longifolia leaves with its possible mechanism of action.
Methods and Results : Fresh leaves of H. longifolia were collected, dried, and extracted with methanol (MEHL). And then the MEHL was subjected to antinociceptive activity test using chemical-induced (acetic acid and formalin test) and heat-induced (hot plate and tail immersion test) pain models. Additionally, the possible mechanism behinds the antinociceptive activity was verified both centrally and peripherally. On the other hand, carrageenan-induced paw edema test was used to determine the anti-inflammatory potential of the extract. Exploratory and motor behavior test were evaluated by the open-field test. Various bioactive compounds responsible for antinociceptive and anti-inflammatory activities wer ... 전체 초록 보기
Methods and Results : Fresh leaves of H. longifolia were collected, dried, and extracted with methanol (MEHL). And then the MEHL was subjected to antinociceptive activity test using chemical-induced (acetic acid and formalin test) and heat-induced (hot plate and tail immersion test) pain models. Additionally, the possible mechanism behinds the antinociceptive activity was verified both centrally and peripherally. On the other hand, carrageenan-induced paw edema test was used to determine the anti-inflammatory potential of the extract. Exploratory and motor behavior test were evaluated by the open-field test. Various bioactive compounds responsible for antinociceptive and anti-inflammatory activities wer ... 전체 초록 보기
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