지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Glucocorticoids are known to have anti-inflammatory effect. To investigate whether corticosterone pretreatment enhances or not lipopolysaccharide (LPS)-induced production of inflammatory mediators, RAW 264.7 cells were pretreated with various concentrations of corticosterone for 24 h and then cultured without corticosterone in the presence or absence of LPS. Our results demonstrated that LPS remarkably increased production of TNF-${\alpha}$, IL-6, IL-$1{\beta}$, vascular endothelial growth factor (VEGF), and NO (nitric oxide). Corticosterone pretreatment significantly attenuated LPS-induced production of TNF-${\alpha}$, IL-$1{\beta}$, and VEGF, while significantly enhanced IL-6 and NO. These findings suggest that corticosterone pretreatment may contribute to LPS-induced inflammatory responses in macrophages via pro- and anti-inflammatory imbalance of inflammatory mediators.
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등록된 정보가 없습니다.
참고문헌 (40)
참고문헌 신청
Chrousos, G. P / 2000 / The HPA axis and the stress response / Endocr. Res 26:513
Wilckens, T / 1995 / Glucocorticoids and immune function:physiological relevance and pathogenic potential of hormonal dysfunction / Trends Pharmacol. Sci 16:193
Annane, D / 2009 / Corticosteroids in the treatment of severe sepsis and septic shock in adults: a systematic review / JAMA 301:2362
Chrousos, G. P / 2000 / The stress response and immune function:clinical implications. The 1999 Novera H. Spector Lecture / Ann. N. Y. Acad. Sci 917:38
Chrousos, G. P / 2000 / Stress, chronic inflammation, and emotional and physical well-being: concurrent effects and chronic sequelae / J. Allergy Clin. Immunol 106(5 Suppl):S275
Wilckens, T / 1995 / Glucocorticoids and immune function:physiological relevance and pathogenic potential of hormonal dysfunction / Trends Pharmacol. Sci 16:193
Annane, D / 2009 / Corticosteroids in the treatment of severe sepsis and septic shock in adults: a systematic review / JAMA 301:2362
Chrousos, G. P / 2000 / The stress response and immune function:clinical implications. The 1999 Novera H. Spector Lecture / Ann. N. Y. Acad. Sci 917:38
Chrousos, G. P / 2000 / Stress, chronic inflammation, and emotional and physical well-being: concurrent effects and chronic sequelae / J. Allergy Clin. Immunol 106(5 Suppl):S275
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