지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.12
- 수록면
- 348 - 354 (7page)
- DOI
- 10.15188/kjopp.2020.12.34.6.348
이용수
초록· 키워드
오류제보하기
Oryeong-san (ORS) is a traditional Korean herbal medicine widely used for renal associated diseases, composed of five medicine herbs; Atractylodes japonica Koidzumi, Cinnamomum cassia Presl, Polyporus umbellatus Fries, Poria cocos Wolf and Alisma orientale Juzepzuk. We studied to improve the convenience of intake and portability by developing modernized dosage forms, and examined the effect on anti-inflammation of ORS. In order to develop the tablet formulation of ORS (ORS-F), the tablets were evaluated on the basis of physical characteristics include diameter, thickness, weight variation, hardness, friability and disintegration. To analyze the marker components of ORS-F, eight index markers from five herbal medicines were chosen. And the method using high performance liquid chromatography (HPLC) with diode-array detector method was established for the simultaneous analysis. The biological activities were examined the effect of ORS-F on pro-inflammation mediated by LPS-stimulation. The production of nitric oxide (NO) and cytokines were determined by reacting cultured medium with griess reagent and enzyme-linked immunosorbent assay (ELISA). The expression of cyclooxygenase-2 (COX-2) and inducible NO synthase (iNOS) were investigated by Western blot and RT-PCR. The anti-oxidant activities of OJS-F increased markedly, in a dose-dependent manner. and, The total phenolic compound and flavonoids contents of OJS-F were 10.20±0.09 ㎍/㎎ and 12.86±0.86 ㎍/㎎. OJS-F which is LPS has diminished in the LPS-induced release of inflammatory mediators (NO, iNOS, COX2 and PGE2) and pro-inflammatory cytokines (TNF-α, IL-6 and IL-1β) from the RAW264.7 macrophages. Therefore, the developed formulation for tablet of ORS-F provide efficiency and usability, and indicated effect of anti-inflammation.
목차
서론
재료 및 방법
결과
고찰
결론
References
참고문헌 (25)
참고문헌 신청
Park J / 2018 / Research about application of Shanghanlun disease pattern identification diagnostic system to 2 cases treated by Oreong-san / J of KMediACS 10:81~94
Oh YC / 2014 / Oryeongsan inibits LPS-induced production of inflammatory mediators via blockade of the NF-kappaB, MAPK pathways and eads to HO-1 induction in macrophage cells / BMC complement Altern Med 14:242~253
Jeon WY / 2012 / Protective effects of the traditional herbal formula Oryeongsan water extract on ethanol-induced acute gastric mucosal injury in rats / Evid Based Complement Alternat Med 2012:438191
Park JK / 2015 / A case report of primary insomnia treated by Oryeong-san decoction / J of KMediACS 7:45~52
Heo J / 2014 / A case report of dysmenorrhea treated by Oryeong-san based on Shanghanlun provisions / J of KMediACS 6:63~70
Oh YC / 2014 / Oryeongsan inibits LPS-induced production of inflammatory mediators via blockade of the NF-kappaB, MAPK pathways and eads to HO-1 induction in macrophage cells / BMC complement Altern Med 14:242~253
Jeon WY / 2012 / Protective effects of the traditional herbal formula Oryeongsan water extract on ethanol-induced acute gastric mucosal injury in rats / Evid Based Complement Alternat Med 2012:438191
Park JK / 2015 / A case report of primary insomnia treated by Oryeong-san decoction / J of KMediACS 7:45~52
Heo J / 2014 / A case report of dysmenorrhea treated by Oryeong-san based on Shanghanlun provisions / J of KMediACS 6:63~70
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
LPS로 유발한 RAW264.7 세포 염증반응에 대한 가감통순산(加減通順散)의 억제 효과
한방재활의학과학회지
2018 .01
-
표준 치료를 받고 있는 제2형 당뇨병 환자에서 오령산 병용 투여의 후향적 약물 상호작용 연구
대한한방내과학회지
2024 .09
-
LPS유도 염증 동물모델에서 오적산의 항염증 효과
대한한의학회지
2021 .06
-
Formosanin C attenuates lipopolysaccharide-induced inflammation through nuclear factor-κB inhibition in macrophages
The Korean Journal of Physiology & Pharmacology
2021 .09
-
오령산(五？散)으로 호전된 일차성 불면증 1례 임상 보고
대한상한금궤의학회지
2015 .01
-
Anti-inflammatory activities of sinensetin on LPS-stimulated L6 skeletal muscle cells
Journal of Biomedical and Translational Research
2019 .01
-
선학초(仙鶴草)추출물의 대식세포에서의 LPS-유도 염증반응에 대한 효능 연구
대한본초학회지(본초분과학회지)
2016 .01
-
Anti-inflammatory Effects of Ethanol Extract of Various Korean Compositae Herbs in LPS-induced RAW 264.7 Macrophages
대한본초학회지(본초분과학회지)
2017 .01
-
오령산에 대한 임상연구 분석
대한한의학방제학회지
2018 .01
-
대두, 홍삼, 진피로 구성된 발효 추출물의 항염증 효능에 관한 연구
대한본초학회지(본초분과학회지)
2015 .01
-
Extract mulberry leaves fermented with Cordyceps militaris exerts anti inflammatory effects in LPS stimulated RAW264.7 macrophage cells by regulating COX-2/iNOS, inflammatory cytokine expression, MAP kinase pathways, the cell cycle and anti oxidant activity
한국실험동물학회 학술발표대회 논문집
2018 .07
-
Chemicals from Cimicifuga dahurica and Their Inhibitory Effects on Pro-inflammatory Cytokine Production by LPS-stimulated Bone Marrow-derived Dendritic Cells
Natural Product Sciences
2018 .09
-
알레르기 후기 반응 염증 억제효과에 관한 淸肌散의실험적 연구
한방안이비인후피부과학회지
2016 .01
-
Comparison of Anti-Inflammation Effects of Specimens Before and After the Oil Extraction of Raphanus sativus L. Seed in RAW 264.7 Macrophage Activated by LPS
셀메드
2023 .05
-
Anti-inflammatory Activity of the Methanol Extract from the Stem of Coriandrum Sativum in RAW 264.7 Cells
대한본초학회지(본초분과학회지)
2018 .01
-
LPS유도 대식세포에서 Kaempferol-7-O-β-D-glucoside의 NO, PGE₂ 및 염증성 사이토카인 생성 저해 효과
생약학회지(Korean Journal of Pharmacognosy)
2016 .12
-
Pretreatment of Low-Dose and Super-Low-Dose LPS on the Production of In Vitro LPS-Induced Inflammatory Mediators
Toxicological Research
2018 .01
-
IL-17A-Producing Foxp3+ Regulatory T Cells and Human Diseases
Immune Network
2017 .10
-
Anti-inflammatory effects of DA-9601, an extract of Artemisia asiatica, on aceclofenac-induced acute enteritis
The Korean Journal of Physiology & Pharmacology
2021 .09
-
Anti-inflammatory Effect of Mangosteen (Garcinia mangostana L.) Peel Extract and its Compounds in LPS-induced RAW264.7 Cells
Natural Product Sciences
2016 .09
이 논문의 저자 정보
이 논문과 함께 이용한 논문
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2021-519-001408955