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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.26 No.1
- 발행연도
- 2021.3
- 수록면
- 67 - 74 (8page)
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초록· 키워드
오류제보하기
Quercetin and resveratrol are found in a variety of fruits and vegetables and have several biological and pharmacological properties. In this study, the effects of quercetin [50 mg/kg, intraperitoneal (i.p.)] and resveratrol (50 mg/kg, i.p.) on zinc chloride (ZnCl₂; 75 mg/kg/d, 2 weeks oral gavage) and sodium metavanadate (SMV; 22.5 mg/kg/d, 2 weeks oral gavage) induced passive avoidance memory retention were investigated in step-through passive avoidance tasks. ZnCl₂ was dissolved in saline and SMV was dissolved in drinking water. Mice received ZnCl₂ or SMV orally for two weeks and were administered quercetin or resveratrol by i.p. injection on day 14, days 12 and 14, or days 10, 12, and 14. At the end of treatment, animals were trained for one day in a step-through passive avoidance task, then alterations in avoidance memory retention were evaluated after 24, 48, 96, and 168 h. Oral consumption of ZnCl₂ and SMV decreased latency time compared with control groups. Both quercetin and resveratrol (50 mg/kg, i.p.) prevented ZnCl₂- and SMV-induced avoidance memory retention impairments and did not significantly alter muscle strength, as demonstrated in rotarod tasks. No significant differences were observed between mice who received single, double, or triple doses of quercetin or resveratrol. The results suggest that quercetin and resveratrol may have preventive effects on ZnCl₂- and SMV-induced memory impairment in male mice.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (102)
참고문헌 신청
Ader R / 1972 / Retention of a passive avoidance response as a function of the intensity and duration of electric shock / Psychon Sci 26:125~128
Afeseh Ngwa H / 2009 / Vanadium induces dopaminergic neurotoxicity via protein kinase C-delta dependent oxidative signaling mechanisms : relevance to etiopathogenesis of Parkinson’s disease / Toxicol Appl Pharmacol 240:273~285
al-Bayati MA / 1989 / Time and dose-response study of the effects of vanadate on rats : morphological and biochemical changes in organs / J Environ Pathol Toxicol Oncol 9:435~455
Anekonda TS / 2006 / Resveratrol－a boon for treating Alzheimer’s disease? / Brain Res Rev 52:316~326
Avila-Costa MR / 2006 / Hippocampal cell alterations induced by the inhalation of vanadium pentoxide(V2O5)promote memory deterioration / NeuroToxicology 27:1007~1012
Afeseh Ngwa H / 2009 / Vanadium induces dopaminergic neurotoxicity via protein kinase C-delta dependent oxidative signaling mechanisms : relevance to etiopathogenesis of Parkinson’s disease / Toxicol Appl Pharmacol 240:273~285
al-Bayati MA / 1989 / Time and dose-response study of the effects of vanadate on rats : morphological and biochemical changes in organs / J Environ Pathol Toxicol Oncol 9:435~455
Anekonda TS / 2006 / Resveratrol－a boon for treating Alzheimer’s disease? / Brain Res Rev 52:316~326
Avila-Costa MR / 2006 / Hippocampal cell alterations induced by the inhalation of vanadium pentoxide(V2O5)promote memory deterioration / NeuroToxicology 27:1007~1012
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