지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 721 - 728 (8page)
이용수
초록· 키워드
오류제보하기
We investigated the protective activities of quercetin (Q) and quercetin-3-${\beta}$-${\small{D}}$-glucoside (Q3G) under $A{\beta}_{25-35}$-injected Alzheimer's disease (AD) model mice. To induce an AD-like disease in an in vivo model, mice were injected with $A{\beta}_{25-35}$ via the intracerebroventricular route. Q and Q3G were administered orally for 14 days at 30 mg/kg/day. Learning and memory functions were evaluated using behavioral experiments that comprise tests like T-maze, Morris water maze, and novel object recognition. The administration of Q and Q3G improved memory and cognitive function, compared with $A{\beta}_{25-35}$-injected control mice in the T-maze and object recognition test. Q and Q3G administration decreased time in order to get to the platform during the Morris water maze test. The group administered Q experienced higher protective effects from long-term spatial memory and learning ability impairments than the group administered Q3G. Furthermore, lipid peroxidation and NO formation in the brain were significantly elevated in $A{\beta}_{25-35}$-injected control mice, and this was inhibited by Q and Q3G. These results demonstrated that Q and Q3G improved $A{\beta}_{25-35}$-induced memory deficits and cognitive impairment and promoted protection in the brain against oxidative stress.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Impact of various vacuum degrees during grinding and storage on the browning, antioxidant activities, quercetin, and quercetin glucoside compounds in onion
한국식품영양과학회 학술대회발표집
2024 .10
-
Synthesis and biological evaluation of flavonol-glucose conjugates for cosmeceutical development
Applied Biological Chemistry
2015 .01
-
Effect of Surface Dielectric Barrier Discharge on the Physiological Activities of Quercetin
한국식품영양학회지
2017 .04
-
Quercetin 유사체가 조골세포 분화에 미치는 영향
한국식품영양과학회지
2023 .10
-
사료 내 Quercetin의 첨가가 육계의 생산성, 혈액 생화학 특성, 혈액 내 면역글로불린과 혈액 내 항산화 인자에 미치는 영향
한국가금학회지
2015 .03
-
Populus tomentiglandulosa improves cognitive impairment by regulating oxidative stress in an amyloid beta25–35-induced Alzheimer’s disease mouse model
한국식품영양과학회 학술대회발표집
2021 .10
-
A novel β-secretase inhibitory peptide from skate skin ameliorate memory and cognitive deficits in amyloid-beta mouse model of Alzheimer`s disease
한국수산과학회 양식분과 학술대회
2017 .05
-
연잎, 상엽, 건조 무 혼합 추출물의 지표성분 wogonin, quercetin 및 quercetin-3-O-glucuronide의 분석법 개발 및 검증
한국식품위생안전성학회지
2018 .01
-
Effects of Quercetin and Resveratrol on Zinc Chloride- and Sodium Metavanadate-Induced Passive Avoidance Memory Retention Deficits in Male Mice
Preventive Nutrition and Food Science
2021 .03
-
Spirulina maxima Extract Improves Learning and Memory Impairments via Inhibiting Phosphorylation of GSK3-βInduced by Intracerebroventricular Injection of Amyloid Beta 1-42 (Aβ1-42) in Mice
한국식품영양과학회 학술대회발표집
2017 .10
-
Effects of 2’-Fucosyllactose on Cognitive and Memory Function in 5X FAD Alzheimer’ Disease Mouse Model
한국식품영양과학회 학술대회발표집
2023 .10
-
Anti-proliferation Effect of Quercetin and Luteolin Derivatives in B16F0, Mouse Melanoma
한국식품영양과학회 학술대회발표집
2021 .10
-
Ameliorating Effect of Korean Edible Plants on Amyloid Beta Peptide-induced Cognitive Impairment in Mice
한국식품영양과학회 학술대회발표집
2020 .10
-
Synthesis of alkyl quercetin derivatives
Applied Biological Chemistry
2015 .01
-
Evaluation of the cytotoxicity of gold nanoparticle-quercetin complex and its potential as a drug delivery vesicle
Journal of applied biological chemistry
2016 .01
-
Biotransformation of quercetin to quercetin 3-O-gentiobioside using engineered Escherichia coli
Applied Biological Chemistry
2016 .01
-
Binding Affinity of Quercetin to Human TAS2Rs
한국식품영양과학회 학술대회발표집
2024 .10
-
3T3-L1 지방전구세포에서 Quercetin이 Matrix Metalloproteinases 억제에 의한 지방세포 분화에 미치는 영향
한국식품영양과학회지
2022 .04
-
Analysis of Rutin and Quercetin in Leaves of Boxthorn
한국약용작물학회 학술대회논문집
2017 .09
-
Quercetin 7-O-glutamate sensitizes Escherichia coli to vancomycin
Applied Biological Chemistry
2016 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0