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논문 기본 정보

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학술저널
저자정보
Leandro dos Santos (Pernambuco Rural Federal University-Serra Talhada Academic Unit (UFRPE-UAST)) Letícia de Oliveira Maciel (Federal Institute of Southern Minas Gerais (IFSULDEMINAS)) Erika Kristina Incerpi Gracia (Federal University of Alfenas (UNIFAL)) Evelise Aline Soares (Federal University of Alfenas (UNIFAL)) Danielle Aparecida Quintino Silva Sarto (Federal Institute of Southern Minas Gerais (IFSULDEMINAS)-Campus Machado) Valério Garrone Barauna (Federal University of Espírito Santo (UFES)) Heder Frank Gianotto Estrela (Jundiaí Medical School (FMJ)) Carollayne Mendonça Rocha (José do Rosário Vellano University (UNIFENAS)) Maria das Graças de Souza Carvalho (José do Rosário Vellano University (UNIFENAS)) Brígida Monteiro Vilas-Boas (Federal Institute of Southern Minas Gerais (IFSULDEMINAS)-Campus Machado) José Antônio Dias Garcia (Federal Institute of Southern Minas Gerais (IFSULDEMINAS)-Campus Machado)
저널정보
한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.26 No.1
발행연도
2021.3
수록면
51 - 57 (7page)

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Cardiovascular diseases are the leading cause of mortality and morbidity worldwide. In this study we compared the effects of oral treatment with red pepper ethereal extracts or simvastatin on dyslipidemia, left ventricle remodeling, and atherosclerotic lesions of low-density lipoprotein (LDL) receptor knockout mice (LDLr<SUP>−/−</SUP>) fed a hyperlipidic diet. Forty 3-month-old male mice were distributed into four groups: control (C; animals fed a standard diet), HL (animals fed a hyperlipidic diet), and HL+P or HL+S (animals fed a hyperlipidic diet plus red pepper ethereal extracts or simvastatin, respectively). After 60 days, treatment with both red pepper ethereal extracts and simvastatin prevented dyslipidemia, atherosclerotic lesion progression, and left ventricle hypertrophy. Our results suggest a cardioprotective effect of red pepper ethereal extracts in LDLr<SUP>−/−</SUP> mice, which is comparable to the well-known effects of simvastatin.

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ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES

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