지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.8
- 수록면
- 287 - 297 (11page)
- DOI
- 10.7783/KJMCS.2020.28.4.287
이용수
초록· 키워드
오류제보하기
Background: Type II diabetes is considered as one of the common diseases. Bangpungtongseongsan (BPS) has been used as a traditional medicine for treating obesity and hypertension in Korea. According to previous reports, it has anti-obesity, anti-chronic asthma, anti-oxidant, and anti-inflammatory properties. However, the effects of BPS on type II diabetes have not yet been elucidated. Thus, in this sutudy, we evaluated the water extracts of BPS using type II diabetes animal models.
Methods and Results: Each group was orally administered with BPS (170, 850 and 1,700 ㎎/㎏) for approximately 13 weeks. A mixture of 150 ㎎/㎏ metformin and 10 ㎎/㎏ sitagliptin (MS) was used as a positive control. The glycated hemoglobin (HbA1c) and glucose levels, and hematological parameters including blood urine nitrogen, creatinine, low density lipoprotein and total cholesterol, were measured using blood samples. Treatment with 170 ㎎/㎏ BPS decreased the HbA1c and glucose levels in blood without affecting the weights of the animals. However, threatment with 1,700 ㎎/㎏ BPS reduced the weights and fatty liver, and increased the blood glucose level in type II diabetes animal models
Conclusions: These results indicate that a low dose of BPS for 13 weeks, which reduces HbA1c and blood glucose levels, could be used for the treatment of type II diabetes. However, further studies are required to elucidate how active ingredients of BPS influence HbA1c and glucose levels in blood.
Methods and Results: Each group was orally administered with BPS (170, 850 and 1,700 ㎎/㎏) for approximately 13 weeks. A mixture of 150 ㎎/㎏ metformin and 10 ㎎/㎏ sitagliptin (MS) was used as a positive control. The glycated hemoglobin (HbA1c) and glucose levels, and hematological parameters including blood urine nitrogen, creatinine, low density lipoprotein and total cholesterol, were measured using blood samples. Treatment with 170 ㎎/㎏ BPS decreased the HbA1c and glucose levels in blood without affecting the weights of the animals. However, threatment with 1,700 ㎎/㎏ BPS reduced the weights and fatty liver, and increased the blood glucose level in type II diabetes animal models
Conclusions: These results indicate that a low dose of BPS for 13 weeks, which reduces HbA1c and blood glucose levels, could be used for the treatment of type II diabetes. However, further studies are required to elucidate how active ingredients of BPS influence HbA1c and glucose levels in blood.
목차
ABSTRACT
서언
재료 및 방법
결과 및 고찰
REFERENCES
참고문헌 (57)
참고문헌 신청
Bakris GL / 2009 / Renal sodium-glucose transport : Role in diabetes mellitus and potential clinical implications / Kidney international 75:1272~1277
Bruke SJ / 2017 / db/db mice exhibit features of human type 2 diabetes that are not present in weight-matched C57BL/6J mice fed a western diet / Journal of Diabetes Research 1017:8503754
Canet MJ / 2015 / Renal xenobiotic transporter expression is altered in multiple experimental models of nonalcoholic steatohepatitis / Drug Metabolism and Disposition 43:266~272
Chandrasekera PC / 2014 / Of rodents and men : Species-specific glucose regulation and type 2 diabetes research / ALTEX 31:157~176
최철수 / 2009 / 인슐린저항성의 발생기전 / 대한내과학회지 77(2):171~177
Bruke SJ / 2017 / db/db mice exhibit features of human type 2 diabetes that are not present in weight-matched C57BL/6J mice fed a western diet / Journal of Diabetes Research 1017:8503754
Canet MJ / 2015 / Renal xenobiotic transporter expression is altered in multiple experimental models of nonalcoholic steatohepatitis / Drug Metabolism and Disposition 43:266~272
Chandrasekera PC / 2014 / Of rodents and men : Species-specific glucose regulation and type 2 diabetes research / ALTEX 31:157~176
최철수 / 2009 / 인슐린저항성의 발생기전 / 대한내과학회지 77(2):171~177
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Effect of Consumption of Whole-Wheat Breads on FBS, HbA1c, and Blood Lipids in Patients with Type 2 Diabetes
Preventive Nutrition and Food Science
2021 .09
-
Effects of Sea rice waste extract on blood glucose level and fatty liver in Type 2 diabetes Mice
한국식품영양과학회 학술대회발표집
2024 .10
-
The Effect of Deglusterol, Peptide Complex on Blood Glucose Regulation and Type II Diabetes Prevention
한국식품영양과학회 학술대회발표집
2020 .10
-
팽화홍삼 분말 및 음료 식이가 Streptozotocin 유발 당뇨쥐의 혈당 및 혈청지질에 미치는 영향
한국식품영양과학회지
2015 .10
-
한국 성인 2형 당뇨병 환자를 위한 당뇨 중재 프로그램 효과에 대한 메타 분석
한국식품영양학회지
2022 .06
-
Sugar-sweetened coffee intake and blood glucose management in Korean patients with type 2 diabetes
한국식품영양과학회 학술대회발표집
2022 .10
-
Effects of Allium hookeri Extracts using EtOH on Blood Glucose in Type II Diabetic Mice
한국식품영양과학회 학술대회발표집
2015 .08
-
Pre-hypertension and the risk of diabetes mellitus incidence using a marginal structural model in an Iranian prospective cohort study
Epidemiology and Health
2018 .01
-
3T3-L1 지방세포 및 제2형 당뇨 마우스 모델에서 건지황 열수 추출물의 항당뇨 효능 연구
한국식품영양과학회지
2018 .10
-
Capsicum annuum L. cultivar DANGJO Amelorated Type 2 Diabetes Induced by High-fat Diet and Streptozotocin
한국식품영양과학회 학술대회발표집
2021 .10
-
Comparative Study on Compositions and Functional Properties of Porcine, Chicken and Duck Blood
한국축산식품학회지
2017 .01
-
A Review of Recent Evidence from Meal-Based Diet Interventions and Clinical Biomarkers for Improvement of Glucose Regulation
Preventive Nutrition and Food Science
2020 .03
-
Physicochemical Properties of Blood Jerky with Various Levels Duck Blood Levels
한국식품영양과학회 학술대회발표집
2024 .10
-
제2형 당뇨 동물모델에서 가시오가피 추출물의 당화혈색소 및 최종당화산물 억제를 통한 혈당조절 효과
한국식품영양과학회지
2016 .07
-
Study on the effect of high blood pressure and blood cholesterol from silkworm peptides using hydrolysis
한국식품영양과학회 학술대회발표집
2023 .10
-
The Effect of Glucose and Glucose Transporter on Regulation of Lactation in Dairy Cow
한국동물번식학회지
2015 .01
-
In-Vitro, In-Vivo 동물모델에서 귀리 유래 수용성 베타-글루칸의 칼로리 제한 효과 작용기전 규명
한국식품영양학회지
2017 .12
-
Fermented Mealworm Extract Supplementation Reduced Fating Blood Glucose Level by Increasing Hepatic Glycogen Synthesis in Type 2 Diabetic Mice
한국식품영양과학회 학술대회발표집
2022 .10
-
Meta-Analysis: Effects of Zinc Supplementation Alone or with Multi-Nutrients, on Glucose Control and Lipid Levels in Patients with Type 2 Diabetes
Preventive Nutrition and Food Science
2019 .03
-
Effects of Allium hookeri on Glucose Metabolism in Type II Diabetic Mice
한국식품영양과학회 학술대회발표집
2015 .08
이 논문의 저자 정보
이 논문과 함께 이용한 논문
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2020-480-001160367