지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.12
- 수록면
- 267 - 274 (8page)
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초록· 키워드
오류제보하기
The larva of Protaetia brevitarsis Lewis (P. brevitarsis), edible insect, is traditionally consumed as alternative source of nutrients and has various health benefits. However, the exact pharmaceutical effects of P. brevitarsis on inflammatory response are still not well understood. Thus, we investigated the anti-inflammatory effects and mechanisms of P. brevitarsis in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. We investigated the effects of P. brevitarsis on the expression levels of inflammatory-related genes, including inflammatory cytokines, prostaglandin E₂ (PGE₂), cyclooxygenase (COX)-2 and inducible nitric oxide synthase (iNOS) in LPS-stimulated RAW264.7 cells. To understand the anti-inflammatory mechanism of P. brevitarsis, we explored the regulatory effect of P. brevitarsis on nuclear factor (NF)-κB and caspase-1 activation. The findings of this study demonstrated that P. brevitarsis inhibits the LPS-induced inflammatory cytokine and PGE₂ levels, as well as COX-2 and iNOS expression. Moreover, we confirmed that the anti-inflammatory effect of P. brevitarsis occurs via suppression of the activation of NF-κB and caspase-1. Conclusively, these findings provide experimental evidence that P. brevitarsis may be useful candidate for the treatment of inflammatory-related diseases.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (22)
참고문헌 신청
안은미 / 2019 / The ameliorative effect of Protaetia brevitarsis Larvae in HFD-induced obese mice / Food Science and Biotechnology 28(4):1177~1186
Beutler B / 2000 / Tlr4 : central component of the sole mammalian LPS sensor / Current Opinion in Immunology 12:20~26
Birrell MA / 2005 / Ikappa-B kinase-2 inhibitor blocks inflammation in human airway smooth muscle and a rat model of asthma / American Journal of Respiratory and Critical Care Medicine 172:962~971
Edwards MR / 2017 / Viral infections in allergy and immunology : How allergic inflammation influences viral infections and illness / The Journal of Allergy and Clinical Immunology 140:909~920
Fedenko ES / 2011 / Cytokine gene expression in the skin and peripheral blood of atopic dermatitis patients and healthy individuals / Self Nonself 2:120~124
Beutler B / 2000 / Tlr4 : central component of the sole mammalian LPS sensor / Current Opinion in Immunology 12:20~26
Birrell MA / 2005 / Ikappa-B kinase-2 inhibitor blocks inflammation in human airway smooth muscle and a rat model of asthma / American Journal of Respiratory and Critical Care Medicine 172:962~971
Edwards MR / 2017 / Viral infections in allergy and immunology : How allergic inflammation influences viral infections and illness / The Journal of Allergy and Clinical Immunology 140:909~920
Fedenko ES / 2011 / Cytokine gene expression in the skin and peripheral blood of atopic dermatitis patients and healthy individuals / Self Nonself 2:120~124
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UCI(KEPA) : I410-ECN-0101-2021-510-001446403