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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
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- 1 - 13 (13page)
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Objective : This study investigated the inflammatory reaction is characterized by over production of inflammatory mediators due to an up-regulation of inflammatory pathways.
Methods : We investigated the anti-inflammatory effects of water extracts from Lonicera japonica and Scutellaria baicalensis in lipopolysaccharide (LPS)-stimulated U937 cells. Each extract suppressed the production of inflammatory mediators (NO, IL-1β, TNF-α, and PGE2) and the expression of inducible NO synthase and cyclooxygenase-2 in LPS- stimulated U937 cells in a dose-dependent manner.
Results : These suggest that the suppression effects were synergistically increased by their combination. Their combination extract also inhibited NF-κB-DNA complex of NF-κB binding activity and translocation of NF-κB from cytosol to nucleus.
Conclusions : Our study suggest that the combination of water-extractable components of L. japonica and S.
baicalensis may be useful for therapeutic drugs against inflammatory immune diseases, probably by suppressing the production of inflammatory mediators.
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참고문헌 (40)
참고문헌 신청
Feldmann M / 1996 / Role of cytokines in rheumatoid arthritis / Annual Review ofImmunology 14:397~440
Isomaki P / 1997 / Pro-and anti-inflammatory cytokines in rheumatoid arthritis / Annals of Medicine 29:499~507
Kotake Y / 1998 / Inhibition of NF-kappaB, iNOS mRNA, COX2mRNA, and COX catalytic activity by phenyl-N-tert-butylnitrone(PBN) / Biochimica Etbiophysica Acta 1448:77~84
Kroncke KD / 1997 / Nitric oxide: cytotoxicity versus cytoprotectionhow, why, when, and where? / Nitric Oxide 1:107~120
Birkenkamp KU / 2001 / The p38MAP kinase inhibitor SB203580 enhances nuclear factor-kappa B transcriptional activity by a non-specific effect upon the ERK pathway / Br J Pharmacol 131:99~107
Isomaki P / 1997 / Pro-and anti-inflammatory cytokines in rheumatoid arthritis / Annals of Medicine 29:499~507
Kotake Y / 1998 / Inhibition of NF-kappaB, iNOS mRNA, COX2mRNA, and COX catalytic activity by phenyl-N-tert-butylnitrone(PBN) / Biochimica Etbiophysica Acta 1448:77~84
Kroncke KD / 1997 / Nitric oxide: cytotoxicity versus cytoprotectionhow, why, when, and where? / Nitric Oxide 1:107~120
Birkenkamp KU / 2001 / The p38MAP kinase inhibitor SB203580 enhances nuclear factor-kappa B transcriptional activity by a non-specific effect upon the ERK pathway / Br J Pharmacol 131:99~107
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