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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.25 No.4
- 발행연도
- 2020.12
- 수록면
- 380 - 388 (9page)
- DOI
- 10.3746/pnf.2020.25.4.380
이용수
초록· 키워드
오류제보하기
Stauntonia hexaphylla (Thunb.) Decaisne and Vaccinium bracteatum Thunb. are commonly used in traditional herbal medicine and food and both exhibit antioxidant and anti-inflammatory effects. Herein, hot-water extracts of Stauntonia hexaphylla (Thunb.) Decaisne and Vaccinium bracteatum Thunb. fruits (1:1 mixture) were used to produce a complex extract NET-1601. The anti-fatigue activity of NET-1601 was evaluated in an in vitro oxidative stress model induced by treating C2C12 myotubes with H2O2. An exhaustive swimming test (EST) in vivo model was established using ICR mice. NET-1601-treated C2C12 myotubes (50, 100, and 200 ㎍/mL) with H₂O₂-induced oxidative stress displayed significantly increased cell viability and ATP content, but significantly decreased levels of reactive oxygen species. All NET-1601-treated EST models demonstrated significantly higher maximum swimming rates than control mice. Furthermore, serum lactate, lactate dehydrogenase activity, non-esterified fatty acid, and intramuscular glycogen levels were higher in NET-1601-treated mice than in control mice. In addition, mRNA levels of regulatory factors involved in muscle mitochondrial fatty acid β-oxidation increased upon NET-1601 treatment. Moreover, catalase, superoxide dismutase, glutathione-S-transferase, and liver glutathione content, and antioxidant activity were higher in NET-1601-treated mice than in control mice. Reduced malondialdehyde levels indicated that NET-1601 treatment inhibited exercise-induced lipid peroxidation. Together, these results suggest that NET-1601 retains antioxidant enzyme activity during oxidative stress, simultaneously enhancing both muscle function via glycogen and fatty acid oxidation, thereby exerting a positive effect on recovery from fatigue.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (37)
참고문헌 신청
Ábrigo J / 2018 / Role of oxidative stress as key regulator of muscle wasting during cachexia / Oxid Med Cell Longev 2018:2063179
Allen DG / 2008 / Skeletal muscle fatigue : cellular mechanisms / Physiol Rev 88:287~332
Ba Vinh L / 2019 / Bioactive triterpene glycosides from the fruit of Stauntonia hexaphylla and insights into the molecular mechanism of its inflammatory effects / Bioorg Med Chem Lett 29:2085~2089
Bejma J / 2000 / Free radical generation and oxidative stress with ageing and exercise : differential effects in the myocardium and liver / Acta Physiol Scand 169:343~351
Couillard A / 2005 / From muscle disuse to myopathy in COPD : potential contribution of oxidative stress / Eur Respir J 26:703~719
Allen DG / 2008 / Skeletal muscle fatigue : cellular mechanisms / Physiol Rev 88:287~332
Ba Vinh L / 2019 / Bioactive triterpene glycosides from the fruit of Stauntonia hexaphylla and insights into the molecular mechanism of its inflammatory effects / Bioorg Med Chem Lett 29:2085~2089
Bejma J / 2000 / Free radical generation and oxidative stress with ageing and exercise : differential effects in the myocardium and liver / Acta Physiol Scand 169:343~351
Couillard A / 2005 / From muscle disuse to myopathy in COPD : potential contribution of oxidative stress / Eur Respir J 26:703~719
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