지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국지능시스템학회 INTERNATIONAL JOURNAL of FUZZY LOGIC and INTELLIGENT SYSTEMS INTERNATIONAL JOURNAL of FUZZY LOGIC and INTELLIGENT SYSTEMS Vol.20 No.3
- 발행연도
- 2020.9
- 수록면
- 219 - 226 (8page)
- DOI
- 10.5391/IJFIS.2020.20.3.219
이용수
초록· 키워드
오류제보하기
A typical genome-wide association study is conducted through a single-phenotype analysis of the correlation between each phenotype and genotype one at a time. Alternatively, a multiple-phenotype analysis of the correlation between multiple phenotypes and a genotype often has many advantages over single-phenotype analysis. For example, statistical power in the association test may be increased in a multiple-phenotype analysis and thus may detect small effects that cannot be identified in a single-phenotype analysis. Of the several multiple-phenotype analytical methods that have been proposed, generalized analysis of molecular variance for mixed-model analysis (GAMMA) is used to analyze many phenotypes simultaneously while considering the population structure. This method shows higher accuracy than the other methods. However, GAMMA has not been widely used because no automated and user-friendly software is available; this is also the case with most other multiple-phenotype analysis methods. In addition, the lack of a parallel-processing option, which is essential in a genome-wide-association-studies analysis, is also prevalent in GAMMA. In this study, we propose an easy-to-use R package for GAMMA called GAMMA Renew (GAMMAR) that performs multiple-phenotype analysis using parallel processing. We evaluate GAMMAR using a recently published yeast dataset to locate trans-regulatory hotspots.
목차
Abstract
1. Introduction
2. Related Work
3. Methods
4. Results
5. Conclusion
References
참고문헌 (19)
참고문헌 신청
C. D. Campbell / 2005 / Demonstrating stratification in a European American population / Nature Genetics 37(8):868~872
A. Helgason / 2005 / An Icelandic example of the impact of population structure on association studies / Nature Genetics 37(1):90~95
A. P. Reiner / 2005 / Population structure, admixture, and aging-related phenotypes in African American adults : the Cardiovascular Health Study / The American Journal of Human Genetics 76(3):463~477
B. F. Voight / 2005 / Confounding from cryptic relatedness in case-control association studies / PLoS Genetics 1(3):e32
M. Berger / 2006 / Hidden population substructures in an apparently homogeneous population bias association studies / European Journal of Human Genetics 14(2):236~244
A. Helgason / 2005 / An Icelandic example of the impact of population structure on association studies / Nature Genetics 37(1):90~95
A. P. Reiner / 2005 / Population structure, admixture, and aging-related phenotypes in African American adults : the Cardiovascular Health Study / The American Journal of Human Genetics 76(3):463~477
B. F. Voight / 2005 / Confounding from cryptic relatedness in case-control association studies / PLoS Genetics 1(3):e32
M. Berger / 2006 / Hidden population substructures in an apparently homogeneous population bias association studies / European Journal of Human Genetics 14(2):236~244
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