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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 373 - 379 (7page)
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Humans have acquired many distinct evolutionary traits after the human-chimpanzee divergence. These phenotypes have resulted from genetic changes that occurred in the human genome and were retained by natural selection. Comparative primate genome analyses reveal that loss-of-function mutations are common in the human genome. Some of these gene inactivation events were revealed to be associated with the emergence of advantageous phenotypes and were therefore positively selected and fixed in modern humans (the “less-ismore” hypothesis). Representative cases of human gene inactivation and their functional implications are presented in this review. Functional studies of additional inactive genes will provide insight into the molecular mechanisms underlying acquisition of various human-specific traits.
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참고문헌 (102)
참고문헌 신청
Bergfeld AK / 2012 / Metabolism of vertebrate amino sugars with N-glycolyl groups: elucidating the intracellular fate of the non-human sialic acid N-glycolylneuraminic acid / J Biol Chem 287:28865~28881
Chou HH / 1998 / A mutation in human CMP-sialic acid hydroxylase occurred after the Homo-Pan divergence / Proc Natl Acad Sci U S A 95:11751~11756
Varki NM / 2011 / Biomedical differences between human and nonhuman hominids: potential roles for uniquely human aspects of sialic acid biology / Annu Rev Pathol 6:365~393
Hayakawa T / 2001 / Alu-mediated inactivation of the human CMP N-acetylneuraminic acid hydroxylase gene / Proc Natl Acad Sci U S A 98:11399~11404
Chou HH / 2002 / Inactivation of CMP-N-acetylneuraminic acid hydroxylase occurred prior to brain expansion during human evolution / Proc Natl Acad Sci U S A 99:11736~11741
Chou HH / 1998 / A mutation in human CMP-sialic acid hydroxylase occurred after the Homo-Pan divergence / Proc Natl Acad Sci U S A 95:11751~11756
Varki NM / 2011 / Biomedical differences between human and nonhuman hominids: potential roles for uniquely human aspects of sialic acid biology / Annu Rev Pathol 6:365~393
Hayakawa T / 2001 / Alu-mediated inactivation of the human CMP N-acetylneuraminic acid hydroxylase gene / Proc Natl Acad Sci U S A 98:11399~11404
Chou HH / 2002 / Inactivation of CMP-N-acetylneuraminic acid hydroxylase occurred prior to brain expansion during human evolution / Proc Natl Acad Sci U S A 99:11736~11741
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