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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 1 - 9 (9page)
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We sought to identify common key regulators and build a gene-metabolite network in different nonalcoholic fatty liver disease (NAFLD) phenotypes. We used a high-fat diet (HFD), a methionine-choline-deficient diet (MCDD) and streptozocin (STZ) to establish nonalcoholic fatty liver (NAFL), nonalcoholic steatohepatitis (NASH) and NAFL+type 2 diabetes mellitus (T2DM) in rat models, respectively. Transcriptomics and metabolomics analyses were performed in rat livers and serum. A functional network-based regulation model was constructed using Cytoscape with information derived from transcriptomics and metabolomics. The results revealed that 96 genes, 17 liver metabolites and 4 serum metabolites consistently changed in different NAFLD phenotypes (42-fold, Po0.05). Gene-metabolite network analysis identified ccl2 and jun as hubs with the largest connections to other genes, which were mainly involved in tumor necrosis factor, P53, nuclear factor-kappa B, chemokine, peroxisome proliferator activated receptor and Toll-like receptor signaling pathways. The specifically regulated genes and metabolites in different NAFLD phenotypes constructed their own networks, which were mainly involved in the lipid and fatty acid metabolism in HFD models, the inflammatory and immune response in MCDD models, and the AMPK signaling pathway and response to insulin in HFD+STZ models. Our study identified networks showing the general and specific characteristics in different NAFLD phenotypes, complementing the genetic and metabolic features in NAFLD with hepatic and extra-hepatic manifestations.
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참고문헌 (24)
참고문헌 신청
Adhikary G / 2008 / C-Jun NH2 terminal kinase(JNK)is an essential mediator of Toll-like receptor 2-induced corneal inflammation / J Leukoc Biol 83 : 991 ~ 997
Armstrong MJ / 2014 / Extrahepatic complications of nonalcoholic fatty liver disease / Hepatology 59 : 1174 ~ 1197
Chen JS / 2014 / Development of a microarray for two rice subspecies : characterization and validation of gene expression in rice tissues / BMC Res Notes 7 : 15 ~
Cline MS / 2007 / Integration of biological networks and gene expression data using Cytoscape / Nat Protoc 2 : 2366 ~ 2382
Cynis H / 2013 / Inhibition of glutaminyl cyclases alleviates CCL2-mediated inflammation of non-alcoholic fatty liver disease in mice / Int J Exp Pathol 94 : 217 ~ 225
Armstrong MJ / 2014 / Extrahepatic complications of nonalcoholic fatty liver disease / Hepatology 59 : 1174 ~ 1197
Chen JS / 2014 / Development of a microarray for two rice subspecies : characterization and validation of gene expression in rice tissues / BMC Res Notes 7 : 15 ~
Cline MS / 2007 / Integration of biological networks and gene expression data using Cytoscape / Nat Protoc 2 : 2366 ~ 2382
Cynis H / 2013 / Inhibition of glutaminyl cyclases alleviates CCL2-mediated inflammation of non-alcoholic fatty liver disease in mice / Int J Exp Pathol 94 : 217 ~ 225
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