Analgesic and antipyretic actions of Muntingia calabura leaves chloroform extract in animal models

Zakaria, ZA; Kumar, G Hanan; Zaid, Siti NH Mohd; Ghani, Marwiza A; Hassan, MH; Hazalin, Nurul AMN; Khamis, Mahirah M; Devi, G Rathna; Sulaiman, MR

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자료유형: 학술저널

저자정보: Zakaria, ZA (Faculty of Biotechnology and Life Sciences, Universiti Industri Selangor) Kumar, G Hanan (Faculty of Biotechnology and Life Sciences, Universiti Industri Selangor) Zaid, Siti NH Mohd (Faculty of Biotechnology and Life Sciences, Universiti Industri Selangor) Ghani, Marwiza A (Faculty of Biotechnology and Life Sciences, Universiti Industri Selangor) Hassan, MH (Faculty of Biotechnology and Life Sciences, Universiti Industri Selangor) Hazalin, Nurul AMN (Faculty of Biotechnology and Life Sciences, Universiti Industri Selangor) Khamis, Mahirah M (Faculty of Biotechnology and Life Sciences, Universiti Industri Selangor) Devi, G Rathna (Faculty of Biotechnology and Life Sciences, Universiti Industri Selangor) Sulaiman, MR (Department of Biomedical Sciences, Faculty of Medicine and Health Science, Universiti Putra Malaysia)

저널정보: 경희한의학연구센터 Oriental pharmacy and experimental medicine Oriental pharmacy and experimental medicine 제7권 제1호

발행연도: 2007.1

수록면: 34 - 40 (7page)

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The present study was carried out to elucidate the potential of Muntingia (M.) calabura leaves chloroform extract (MCCE) as antinociceptive, anti-inflammatory and antipyretic agents using various animal models. The dried powdered leaves of M. calabura (20 g) were soaked in chloroform for 72 h and the supernatant obtained was then evaporated to dryness. The crude dried extract (0.912 g), dissolved in dimethyl sulfoxide (1:20; w/v) and considered as a stock solution (100% concentration/strength), was then diluted to the concentrations of 10 and 50% and used together in all experimental models. The MCCE was found to show significant (P < 0.05) antinociceptive and antipyretic activities, but less remarkable anti-inflammatory activity. Only the antinociceptive activity of MCCE measured using the abdominal constriction test and in the first phase of the formalin test occurred in a concentration-dependent manner. The anti-inflammatory activity of 50 and 100% concentrations MCCE was observed only at the range of time interval of 60 - 120 and 60 min, respectively. Based on the results, we conclude that the M. calabura leaves chloroform extract possessed remarkable antinociceptive and antipyretic, but less effective anti-inflammatory, activities and thus justifies the Peruvian folklore claims of its medicinal values.

#Muntingia calabura #Chloroform extract #Antinociceptive #Anti-inflammatory #Antipyretic

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이 논문의 저자 정보

Zakaria, ZA

소속기관 Department of Biomedical Sciences, Faculty of Medicine Health Sciences, Universiti Putra Malaysia

주요연구분야 의약학 > 한의학

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Kumar, G Hanan