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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
대한한방내과학회 대한한방내과학회지 대한한방내과학회지 제29권 제3호
발행연도
2008.1
수록면
554 - 566 (13page)

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Objectives : Modified Gamgil-tang is a prescription commonly used for respiratory diseases. This thesis was carried out to check the treatment effects and diversity of drug formulation by comparing extraction method of ethanol and water of modified Gamgil-tang. Methods : All experiments were carried out with water and 50% ethanol extraction for comparison. In vivo experiment, hyaluronidase inhibitory effects and trypsin inhibitory effects were tested to measure the anti-inflammatory effects activity. Scavenging effects of DPPH free radical, xanthine oxidase inhibitory effects and inhibition on TBA-RS formation were experimented to measure anti-oxidative effects. With the in vivo experiment, ICR group mice and SD group rats were used as experimental animals. An anti-inflammatory effects experiment were carried out to measure the action on carrageenin-induced hind paw edema; analgesic effects were measured using writhing syndrome induced by 0.7% acetic acid in mice; antipyretic effect was measured using endotoxin, and inhibitory effects of increase vascular permeability induced by 0.5% histamine were measured. Results : For extraction of glycyrrhizin contents, ethanol extract was extracted 2 times of that of water extract. Anti-inflammatory effects showed high in ethanol extract. Anti-oxidative effects measured high in ethanol extract. No significant result was found in inhibition on TBA-RS formation. Analgesic effects were found to be similar in water and ethanol extract. Antipyretic effects were found to be stronger in water extract. Inhibitory effects of increase vascular permeability induced by 0.5% histamine showed stronger in ethanol extract. Conclusion : By measuring anti-inflammatory effects, analgesic effects, antipyretic effects, anti-oxidative effects, and histamine permeation inhibition effects both in water extract and ethanol extract after adding agents such as Mentha Herba, Gardeniae Fructus, and propolis to existing Gamgil-Tang, ethanol extract was found to be more effective in anti-inflammatory effects, analgesic effects, anti-oxidative effects, and histamine permeation inhibition effects. The converse was found for antipyretic effect.
#Gamgil-tang #anti-inflammatory #analgesic #anti-oxidative #histamine

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참고문헌 (26)

참고문헌 신청
Inoue T / 2002 / Antiallergic effect of flavoid glycosides obtained from Mentha piperita L / Biol. Pham. Bull 25 : 256 ~ 259 google schola Kim, K. T. / 2005 / Antimicrobial, Anti-inflammatory, and Anti-oxidative effects of Water- and Ethanol-extracted Brazilian Propolis / Food Science and Biotechnology 14 (4) : google schola Kitagawa, I. / 1998 / Quantitative determination of constituents in various Licorice roots by means of High Performance Liquid Chromatography / Yakugaku Zasshi 118 : 519 ~ 5 google schola Shin, T. Y. / 1998 / Antiallergic activity of Menthae herba / Kor. J. Pharmacogn 29 (3) : 248 ~ 253 google schola 康秉秀 / 1998 / 本草學 / 永林社 : 142 ~ 144 google schola

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