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논문 기본 정보

자료유형
학술저널
저자정보
Pandurangan, Subash-Babu (Molecular Biology Research Lab, Department of Food science and Nutrition, College of Food and Agricultural Science, King Saud University) Paul, Antony Samy (Division of Ethnopharmacology, Entomology Research Institute, Loyola College) Savarimuthu, Ignacimuthu (Division of Ethnopharmacology, Entomology Research Institute, Loyola College) Ali, Alshatwi A (Molecular Biology Research Lab, Department of Food science and Nutrition, College of Food and Agricultural Science, King Saud University)
저널정보
한국응용약물학회 Biomolecules & Therapeutics(구 응용약물학회지) Biomolecules & therapeutics 제21권 제5호
발행연도
2013.1
수록면
391 - 397 (7page)

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In the present study, we aimed to analyze the antinociceptive, immunomodulatory and antipyretic activities of nymphayol were investigated in wistar rats and mice. Antinociceptive effect was evaluated by acetic acid induced writhing, formalin induced paw licking and hot-plate tests. Immunomodulatory activity was assessed by neutrophil adhesion test, humoral response to sheep red blood cells, delayed-type hypersensitivity, phagocytic activity and cyclophosphamide induced myelosuppression. Antipyretic activity was evaluated by yeast induced hyperthermia in rats. Nymphayol produced significant (p<0.05) antinociceptive activity in acetic acid induced writhing response and late phase of the formalin induced paw licking response. Pre-treatment with nymphayol (50 mg/kg, oral) evoked a significant increase in neutrophil adhesion to nylon fibres. The augmentation of humoral immune response to sheep red blood cells by nymphayol (50 mg/kg) was evidenced by increase in antibody titres in rats. Oral administration of nymphayol (50 mg/kg) to rats potentiated the delayed-type hypersensitivity reaction induced by sheep red blood cells. Treatment with nymphayol showed a significant (p<0.05) reduction in pyrexia in rats. The results suggest that nymphayol possesses potent anti-nociceptive, immunomodulatory and antipyretic activities.

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