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자료유형
학술저널
저자정보
Park, Dal-Soo (Department of Veterinary Medicine, Graduate School, Cheju National University) Lee, Ki-Hyun (Department of Veterinary Medicine, Graduate School, Cheju National University) Kim, Hee-Chul (Department of Veterinary Medicine, Graduate School, Cheju National University) Ahn, Mee-Jung (Department of Veterinary Medicine, Graduate School, Cheju National University) Moon, Chang-Jong (Department of Veterinary Medicine, Graduate School, Cheju National University) Ko, Myung-Soon (Department of Veterinary Medicine, Graduate School, Cheju National University) Lee, Kyoung-Kap (Department of Veterinary Medicine, Graduate School, Cheju National University) Go, Gyung-Min (Provincial Fisheries Resources Research Institute) Shin, Tae-Kyun (Department of Veterinary Medicine, Graduate School, Cheju National University)
저널정보
경희한의학연구센터 Oriental pharmacy and experimental medicine Oriental pharmacy and experimental medicine 제5권 제3호
발행연도
2005.1
수록면
231 - 235 (5page)

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A limited number of studies have been conducted on the bioactivity of Callophyllis japonica (C. japonica), which is a red seaweed that is traditional in the oriental diet. In this report, the hepatoprotective effect of C. japonica was studied in a carbon tetrachloride $(CCl_4)-induced$ hepatotoxicity model in rats. A single intraperitoneal injection of 1.25 ml/kg of 20% $CCl_4$ in olive oil produced an elevated level of serum glutamic pyruvic transaminase (SGPT) and increased enzyme activity of serum glutamic oxaloacetic transaminase (SGOT). Pre-treatment with C. japonica (150 mg/kg/d) for 3 days in $CCl_4-injected$ rats reduced the levels of SGPT and SGOT compared with control levels (P < 0.05), while higher doses (300 and 600 mg/kg) were ineffective. The administration of C. japonica (150 mg/kg/d) for 3 days after the $CCl_4$ injection in rats was ineffective at reducing SGPT and SGOT. The histopathological findings in each group largely agreed with the biochemical data. The results of this study support the suggestion that C. japonica has a hepatoprotective effect on chemical-induced liver injury.

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