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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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The protective effect of AI-1367 (Alnus japonica extract) on liver injury was investigated. Primary rat hepatocyte intoxication was induced by tert-butyl hydroperoxide (tBH), carbon tetrachloride ($CCl_4$), or D-glactosamine (D-GalN). Liver injury was induced by $CCl_4$, D-GalN or MCD (methionine choline deficient)-diet in mouse. The cellular leakage of lactate dehyrogenase and cell viability followed by the treatment of hepatotoxicants were significantly improved by AI-1367 treatment at a concentration range of 5~50 ${\mu}g/ml$ for tBH, 5~50 ${\mu}g/ml$ for D-GalN, and 5~100 ${\mu}g/ml$ for $CCl_4$, respectively. Treatment with AI-1367 (20, 10, 5 mg/kg, p.o.) on liver injury induced by subcutaneous injection of $CCl_4$ or D-GalN reduced significantly the levels of aspartate transaminase and alanine transaminase in serum. Histological observations revealed that fatty acid changes, hepatocyte necrosis and inflammatory cell infiltration in $CCl_4$ (D-GalN)-induced liver injury was improved by administration of AI-1367. AI-1367 treatment (10, 5, 2.5 mg/kg, p.o.) also significantly recovered the body weight change and serum levels of aspartate transaminase, alanine transaminase and triglyceride in liver injury induced by MCD diet. From these results, AI-1367 shows protective effects against tBH, $CCl_4$, D-GalN, or MCD diet-induced hepatotoxicity in vitro or in vivo.
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참고문헌 (22)
참고문헌 신청
Lim, H. K. / 1999 / Protective and therapeutie effects of Malloti cortex extract on carbon tetrachloride and glactosamine-induced hepatotoxicity in rats / J. Appl. Pharmacol 7:35
Lee, U. E. / 2011 / Mechanisms of hepatic fibrogenesis / Best Pract. Res. Clin. Gastroenterol 25:195
Kim, K. A. / 2009 / Current status of liver diseases in korea: Toxic and alcoholic liver diseases / Korean J. Hepatol 15:29
이동석 / 2004 / 비알코올성 지방간염의 진단 및 간섬유화 정도의 예측인자 / 대한내과학회지 67(3):231~240
1985 / Jungyakdesajon Sohakkyan / Sanghae Science pub :413~415
Lee, U. E. / 2011 / Mechanisms of hepatic fibrogenesis / Best Pract. Res. Clin. Gastroenterol 25:195
Kim, K. A. / 2009 / Current status of liver diseases in korea: Toxic and alcoholic liver diseases / Korean J. Hepatol 15:29
이동석 / 2004 / 비알코올성 지방간염의 진단 및 간섬유화 정도의 예측인자 / 대한내과학회지 67(3):231~240
1985 / Jungyakdesajon Sohakkyan / Sanghae Science pub :413~415
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