메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류

추천
검색

논문 기본 정보

자료유형
학술저널
저자정보
Lee, Yun-Kyung (Laboratory of Pharmacology, College of Pharmacy [BK21 project] and Research Institute for Drug Development, Pusan National University) Kim, Kye-Ok (Laboratory of Pharmacology, College of Pharmacy [BK21 project] and Research Institute for Drug Development, Pusan National University) Kim, Hyo-Lim (Laboratory of Pharmacology, College of Pharmacy [BK21 project] and Research Institute for Drug Development, Pusan National University) Sacket, Santosh J (Laboratory of Pharmacology, College of Pharmacy [BK21 project] and Research Institute for Drug Development, Pusan National University) Han, Mi-Jin (Laboratory of Pharmacology, College of Pharmacy [BK21 project] and Research Institute for Drug Development, Pusan National University) Jo, Ji-Yeong (Laboratory of Pharmacology, College of Pharmacy [BK21 project] and Research Institute for Drug Development, Pusan National University) Im, Dong-Soon (Laboratory of Pharmacology, College of Pharmacy [BK21 project] and Research Institute for Drug Development, Pusan National University)
저널정보
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제30권 제9호
발행연도
2007.1
수록면
1,096 - 1,101 (6page)

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색

초록· 키워드

오류제보하기
Previously, we reported on the distinct effects of bioactive lysophospholipids, including lysophosphatidic acid (LPA), lysophosphatidylcholine (LPC), and sphingosylphosphorylcholine (SPC), on membrane potentials in rat C6 glioma cells. In the present report we have tested lysophosphatidylserine (LPS), another bioactive lysophospholipid, on membrane potentials in the same cell line. Membrane potentials were estimated by measuring the fluorescence changes of DiBAC-loaded glioma cells. LPS largely increased membrane potentials in a concentration-dependent manner. The LPS-induced membrane potential increases were not affected by treatment with pertussis toxin, implying no involvement of $G_{i/o}$ proteins. In contrast toother lysophospholipids, the LPS-induced membrane potential increase was not diminished by a $Na^{+}$-free media but was enhanced by suramin. Furthermore, this change was blunted by EIPA, an inhibitor of $Na^{+}/H^{+}$ exchanger, but not by SITS, a specific inhibitor of bicarbonate transporter. Our observations suggest that LPS acts on membrane potentials in a unique manner in the C6 glioma cells, although the precise action mechanism requires additional investigation.

목차

등록된 정보가 없습니다.

참고문헌 (0)

참고문헌 신청

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0