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논문 기본 정보

자료유형
학술저널
저자정보
Lee Yun-Kyung (Laboratories of Pharmacology, College of Pharmacy and Research Institute for Drug Development, Pusan National University) Liu Yong-Hong (Marine Natural Product, College of Pharmacy and Research Institute for Drug Development, Pusan National University) Jung Jee-H. (Marine Natural Product, College of Pharmacy and Research Institute for Drug Development, Pusan National University) Im Dong-Soon (Laboratories of Pharmacology, College of Pharmacy and Research Institute for Drug Development, Pusan National University)
저널정보
한국응용약물학회 The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology 제14권 제2호
발행연도
2006.1
수록면
110 - 113 (4page)

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We tested effect of sarcotride A, a bioactive cyclitol derivative from a marine sponge, on membrane potential in C6 glioma cells. Membrane potential was estimated by measuring fluorescence change of DiBAC-loaded glioma cells. Sarcotride A increased membrane potential in a concentration-dependent manner. We tested effects of pertussis toxin, U73122, EIPA, and $Na^+-free$ media on sarcotride A-induced increase of membrane potential to investigate involvement of G proteins, phospholipase C, $Na^+/H^+$ exchanger, and $Na^+$ channels. However, we were not able to observe any significant effect of those pharmacological inhibitors, excluding the involvement of the molecules as candidate targets or signaling molecules of sarcotride A-induced increase of membrane potential. Further investigation is necessary to elucidate action mechanism of sarcotride A.

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