Glioma Epidemiology in the Central Tunisian Population: 1993-2012

Trabelsi, Saoussen; Brahim, Dorra H'mida-Ben; Ladib, Mohamed; Mama, Nadia; Harrabi, Imed; Tlili, Kalthoum; Yacoubi, Mohamed Tahar; Krifa, Hedi; Hmissa, Sihem; Saad, Ali; Mokni, Moncef

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저자정보: Trabelsi, Saoussen (Department of Cytogenetics, Molecular genetics and Reproductive Biology, Farhet Hached University Hospital) Brahim, Dorra H'mida-Ben (Department of Cytogenetics, Molecular genetics and Reproductive Biology, Farhet Hached University Hospital) Ladib, Mohamed (Department of Neurosurgery, Sahloul University Hospital) Mama, Nadia (Department of Radiology, Sahloul University Hospital) Harrabi, Imed (Department of Community and Preventive Medicine, Farhet Hached University Hospital) Tlili, Kalthoum (Department of Radiology, Sahloul University Hospital) Yacoubi, Mohamed Tahar (Department of Cytopathology, Farhet Hached University Hospital) Krifa, Hedi (Department of Neurosurgery, Sahloul University Hospital) Hmissa, Sihem (Department of Cancer Registry of the Centre of Tunisia, Farhet Hached University Hospital) Saad, Ali (Department of Cytogenetics, Molecular genetics and Reproductive Biology, Farhet Hached University Hospital) Mokni, Moncef (Department of Cytopathology, Farhet Hached University Hospital)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제20호

발행연도: 2014.1

수록면: 8,753 - 8,757 (5page)

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Background: Glioma is a heterogeneous central nervous system (CNS) tumor group that encompasses different histological subtypes with high variability in prognosis. The lesions account for almost 80% of primary malignant brain tumors. The aim of this study is to extend our understanding of the glioma epidemiology in the central Tunisian region. Materials and Methods: We analyzed 393 gliomas recorded in cancer registry of central Tunisia from 1993 to 2012. Crude incidence rates (CR) and world age-standardized rates (ASR) were estimated using annual population data size and age structure. Statistic correlations were established using Chi-square and Kaplan-Meier test. Results: Tunisian glioma patients were identified with a mean age at diagnosis of 48 years and 1.5 sex ratio (male/female). During the 19 years period of study the highest incidence value was observed in male group between 1998 and 2002 (CR: 0.28, ASR: 0.3). Incidence results underline increasing high grade glioma occurring in the adulthood in the last period (2007-2012). Median survival was 27 months, with 1-, 2- and 5-year survival rates of 42%, 30% and 26%, respectively. Survival was greater in patients with younger age, lower tumor grade, infratentrial tumor location and undergoing a palliative treatment. Conclusions: This central Tunisia gliomas registry study provides important information that could improve glioma management and healthcare practice.

#Glioma #epidemiology #incidence #Tunisia #trends

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Trabelsi, Saoussen

소속기관 Department of Cytogenetics, Molecular Genetics and Reproductive Biology, Farhat Hached University Ho