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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제27권 제6호
- 발행연도
- 2004.1
- 수록면
- 640 - 645 (6page)
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초록· 키워드
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Histone deacetylase inhibitors are new class of chemotherapeutic drugs able to induce tumor cell apoptosis and／or cell cycle arrest. Trichostatin A, an antifungal antibiotic, and HC-toxin are potent and specific inhibitors of histone deacetylase activity. In this study, we have examined the antiproliferative activities of trichostatin A and HC-toxin in estrogen receptor positive human breast cancer, T47D cells. Both trichostatin A and HC-toxin showed potent antiprolifer-ative efficacy and cell cycle arrest at $G_2/M$ in T47D human breast cancer cells in a dose-dependent manner. Trichostatin A caused potent apoptosis of T47D human breast cancer cells and trichostatin A-induced apoptosis might be involved in an increase of caspase-3／7 activity. HC-toxin evoked apoptosis of T47D cells and HC-toxin induced apoptosis might not be medi-ated through direct increase in caspase-3/7 activity. We have identified potent activities of anti-proliferation, apoptosis, and cell cycle arrest of trichostatin A and HC-toxin in estrogen receptor positive human breast cancer cell line T47D.
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Estrogen Receptor Enhances the Antiproliferative Effects of Trichostatin A and HC-toxin in Human Breast Cancer Cells
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2004 .01
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Effect of Botulinum Toxin A on Proliferation and Apoptosis in the T47D Breast Cancer Cell Line
Asian Pacific journal of cancer prevention : APJCP
2013 .01
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Apoptotic Death in MDA-MB-231 Human Breast Cancer Cell Induced by Trichostatin A
대한약학회 학술대회
2000 .01
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The Histone Deacetylase Inhibitor Trichostatin A Sensitizes Human Renal Carcinoma Cells to TRAIL-Induced Apoptosis through Down-Regulation of c-FLIP<sub>L</sub>
Biomolecules & Therapeutics(구 응용약물학회지)
2015 .01
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New HDAC inhibitor, IN2001 induces apoptosis/cell cycle arrest in human breast cancer cells
한국응용약물학회 추계학술발표논문집
2003 .01
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New HDAC inhibitor, IN2001 induces apoptosis/cell cycle arrest in human breast cancer cells
환경독성보건학회 심포지엄 및 학술대회
2003 .10
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Antitumor Activity of Histone Deacetylase Inhibitor Trichostatin A in Osteosarcoma Cells
Asian Pacific journal of cancer prevention : APJCP
2012 .01
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Histone deacetylase inhibitor Trichostatin A enhanced the efficiency of adenovirus mediated gene transfer into non-small cell lung cancer cells
대한약학회 학술대회
2003 .01
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Anti-Cancer Effect of IN-2001 in MDA-MB-231 Human Breast Cancer
Biomolecules & Therapeutics(구 응용약물학회지)
2012 .01
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Trichostatin A-induced Apoptosis is Mediated by Kruppel-like Factor 4 in Ovarian and Lung Cancer
Asian Pacific journal of cancer prevention : APJCP
2014 .01
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Anti-Cancer Effect of IN-2001 in T47D Human Breast Cancer
Biomolecules & Therapeutics(구 응용약물학회지)
2012 .01
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The effect of histone deactylase inhibitors on the cell proliferation and apoptosis in human breast cancer cell lines
환경독성보건학회 심포지엄 및 학술대회
2004 .11
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A Histone Deacetylase Inhibitor, Trichostatin A, Enhances adiosensitivity by Abrogating G2/M Arrest in Human Carcinoma Cells
Cancer Research and Treatment
2005 .01
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Effect of trichostatin A (TSA) treatment on development of reconstructed mouse embryo
한국실험동물학회 학술발표대회 논문집
2010 .08
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Inhibitory Effects of Extracts of Houttuynia cordata Thumb (Saururaceae) on Cytokine Release of Human Monocytic THP-1 Cells and Human Eosinophilic EoL-1 Cells
대한의생명과학회지
2010 .12
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IN2001 is a Novel Histone Deacetylase Inhibitor with Potent Antitumor Activity against Breast Cancer in Vitro and in Vivo.
환경독성보건학회 심포지엄 및 학술대회
2005 .05
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Cadmium Induces Cell Cycle Arrest and Change in Expression of Cell Cycle Related Proteins in Breast Cancer Cell Lines
Toxicological Research
2005 .03
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Trichostatin A Exacerbates Atherosclerosis in Hyperlipidemic Mice
한국실험동물학회 학술발표대회 논문집
2004 .06
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