지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제27권 제5호
- 발행연도
- 2004.1
- 수록면
- 554 - 561 (8page)
이용수
초록· 키워드
오류제보하기
Trichostatin A, an antifungal antibiotics, and HC-toxin are potent and specific inhibitors of histone deacetylase activity. Histone deacetylase inhibitors are new class of chemotherapeutic drugs able to induce tumor cell apoptosis and/or cell cycle arrest. In this study, the antiproliferative activities of trichostatin A and HC-toxin were compared between estrogen receptor positive human breast cancer cell MCF-7 and estrogen receptor negative human breast cancer cell MDA-MB-468. Trichostatin A and HC-toxin showed potent antiproliferative activity in both MCF-7 and MDA-MB-468 cells. In MCF-7 cells that contain high level estrogen receptor, trichostatin A and HC-toxin brought about three-times more potent cell growth inhibitory effect than estrogen receptor negative MDA-MB-468 cells. Both trichostatin A and HC-toxin showed cell cycle arrest at G$_2$/M phases of MCF-7 and MDA-MB-468 cells in a dose- and time- depen- dent manner. Trichostatin A and HC-toxin also induced apoptosis from MCF-7 and MDA-MB-468 cells in a dose- and time-dependent manner. Results of this study suggested that antipro-liferative effects of trichostatin A and HC-toxin might be involved in estrogen receptor signaling pathway, but cell cycle arrest and apoptosis of trichostatin A and HC-toxin might not be involved in estrogen receptor system of human breast cancer cells.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Antiproliferative Effect of Trichostatin A and HC-Toxin in T47D Human Breast Cancer Cells
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2004 .01
-
Apoptotic Death in MDA-MB-231 Human Breast Cancer Cell Induced by Trichostatin A
대한약학회 학술대회
2000 .01
-
Estrogen Modulation of Human Breast Cancer Cell Growth
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1997 .01
-
Effect of Botulinum Toxin A on Proliferation and Apoptosis in the T47D Breast Cancer Cell Line
Asian Pacific journal of cancer prevention : APJCP
2013 .01
-
Effects of HIF-1α/VP16 Hybrid Transcription Factor on Estrogen Receptor in MCF-7 Human Breast Cancer Cells
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
2005 .01
-
New HDAC inhibitor, IN2001 induces apoptosis/cell cycle arrest in human breast cancer cells
한국응용약물학회 추계학술발표논문집
2003 .01
-
Mechanisms of Inhibitory Ah Receptor-Estrogen Receptor Crosstalk in Breast Cancer Cells
한국환경성돌연변이·발암원학회지
2003 .09
-
The Histone Deacetylase Inhibitor Trichostatin A Sensitizes Human Renal Carcinoma Cells to TRAIL-Induced Apoptosis through Down-Regulation of c-FLIP<sub>L</sub>
Biomolecules & Therapeutics(구 응용약물학회지)
2015 .01
-
Prediction and Analysis of Ligands against Estrogen Related Receptor Alpha
Asian Pacific journal of cancer prevention : APJCP
2013 .01
-
유방암종괴의 Estrogen 수용체에 대한 임상적 고찰
Annals of Surgical Treatment and Research
1990 .06
-
에스트로겐 수용체 양성 MCF-7 유방암 세포주에 대한 costunolide의 항암효과
동의생리병리학회지
2013 .01
-
TCDD induced micronuclei in estrogen receptor positive human breast cancer cells
대한약학회 학술대회
2000 .01
-
Treatment with octylphenol can lead to stimulate breast cancer cell growth via the alterations of cyclin D1 and p21 genes in human breast cancer cells through an estrogen receptor-mediated signaling pathway in breast cancer xenografted mice
한국실험동물학회 학술발표대회 논문집
2013 .08
-
Antiestrogen, Trans-Tamoxifen Modulation of Human Breast Cancer Cell Growth
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1997 .01
-
Effects of zinc and resveratrol on cadmium-induced apoptosis and cell arrest in MCF-7 and MDA-MB-231 cells
대한약학회 학술대회
2003 .01
-
Anti-Cancer Effect of IN-2001 in MDA-MB-231 Human Breast Cancer
Biomolecules & Therapeutics(구 응용약물학회지)
2012 .01
-
156 . Estrogen and Progesteron Receptor in Human Breast Cancer in Korea
대한외과학회 학술대회 초록집
1988 .11
-
Estrogen 수용체 및 Progesterone 수용체 함량이 암환자의 예후에 미치는 영향
Annals of Surgical Treatment and Research
1990 .01
-
$Ginsenoside-R_{b1}$ Acts as a Weak Phytoestrogen in MCF-7 Human Breast Cancer Cells
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2003 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0