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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 저널정보
- 한국응용약물학회 한국응용약물학회 추계학술발표논문집 한국응용약물학회 2003년도 Annual Meeting of KSAP : International Symposium on Pharmaceutical and Biomedical Sciences on Obesity
- 발행연도
- 2003.1
- 수록면
- 90 - 90 (1page)
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이 논문의 연구 히스토리 (2)
2003
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The acetylation of histone is one of the mechanisms involved in the regulation of gene expression and is tightly controlled by two core enzymes, histone acetyltransferase (HAT) and deacetylase (HDAC). There are several reports that imbalance of HAT and HDAC activity is associated with abnormal behavior of the cells in morphology, cell cycle, differentiation, and carcinogenesis. Recently, an increasing number of structurally diverse HDAC inhibitors have been identified that inhibit proliferation and induce differentiation and/or apoptosis of tumor cells in vivo and in vitro. In this study, we have investigated the effects of novel HDAC inhibitors, IN2001 on ER positive and ER negative human breast cancer cell lines. The growth inhibition, cell cycle arrest and apoptosis of cells by HDAC inhibitors were determined using SRB assay, DNA fragmentation, and flow cytometry. We found that IN 2001 as well as Trichostatin A inhibited cell growth dose-dependently in both ER positive and ER negative human breast cancer cell lines. The growth inhibition with HDAC inhibitors was associated with profound morphological change. The result of cell cycle analysis after 24 h exposure of IN2001 showed G2-M cell cycle arrest in MCF-7 cell and apoptosis in T47D and MDA-MB-231 cell. In summary, IN2001 has antiproliferative effect on human breast cancer cells regardless of the expression of estrogen receptor. These findings heights the possibility of developing HDAC inhibitors as potential anticancer therapeutic agents for the treatment of breast cancer.
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New HDAC inhibitor, IN2001 induces apoptosis/cell cycle arrest in human breast cancer cells
대한약학회 학술대회
2003 .01
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New HDAC inhibitor, IN2001 induces apoptosis/cell cycle arrest in human breast cancer cells
환경독성보건학회 심포지엄 및 학술대회
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EFFECT OF HDAC INHIBITOR, IN-2001 IN HUMAN BREAST CANCER CELLS
환경독성보건학회 심포지엄 및 학술대회
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Anti-Cancer Effect of IN-2001 in T47D Human Breast Cancer
Biomolecules & Therapeutics(구 응용약물학회지)
2012 .01
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The effects of HDAC inhibitors on proliferation and apoptosis in PC3 cells
환경독성보건학회 심포지엄 및 학술대회
2004 .05
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Effects of Down-regulation of HDAC6 Expression on Proliferation, Cell Cycling and Migration of Esophageal Squamous Cell Carcinoma Cells and Related Molecular Mechanisms
Asian Pacific journal of cancer prevention : APJCP
2013 .01
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Anti-Cancer Effect of IN-2001 in MDA-MB-231 Human Breast Cancer
Biomolecules & Therapeutics(구 응용약물학회지)
2012 .01
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HDAC1 Expression in Invasive Ductal Carcinoma of the Breast and Its Value as a Good Prognostic Factor
Journal of Pathology and Translational Medicine
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HDAC6 siRNA Inhibits Proliferation and Induces Apoptosis of HeLa Cells and its Related Molecular Mechanism
Asian Pacific journal of cancer prevention : APJCP
2012 .01
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ANTI-TUMOR ACTIVITY OF HDAC INHIBITORS THROUGH CELL CYCLE PRREST AND APOPTOSIS IN VITRO AND IN VIVO BREAST CANCER MODEL
환경독성보건학회 심포지엄 및 학술대회
2005 .05
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Effect of Trichostatin A on Anti HepG2 Liver Carcinoma Cells: Inhibition of HDAC Activity and Activation of Wnt/β-Catenin Signaling
Asian Pacific journal of cancer prevention : APJCP
2014 .01
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Isotype-Specific Inhibition of Histone Deacetylases: Identification of Optimal Targets for Radiosensitization
Cancer Research and Treatment
2016 .01
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Histone Deacetylases and their Inhibitors as Potential Therapeutic Drugs for cholangiocarcinoma - Cell Line findings
Asian Pacific journal of cancer prevention : APJCP
2013 .01
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Selective Inhibition of Bicyclic Tetrapeptide Histone Deacetylase Inhibitor on HDAC4 and K562 Leukemia Cell
Asian Pacific journal of cancer prevention : APJCP
2013 .01
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Over-Expression of Beclin-1 Facilitates Acquired Resistance to Histone Deacetylase Inhibitor-Induced Apoptosis
Asian Pacific journal of cancer prevention : APJCP
2014 .01
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Sequence-Dependent Radiosensitization of Histone Deacetylase Inhibitors Trichostatin A and SK-7041
Cancer Research and Treatment
2013 .01
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Novel $\delta$-Lactam base Histone Deacetylase Inhibitors: Synthesis and Biological Evaluation I.
대한약학회 학술대회
2003 .01
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Cadmium Induces Cell Cycle Arrest and Change in Expression of Cell Cycle Related Proteins in Breast Cancer Cell Lines
Toxicological Research
2005 .03
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Trichostatin A Attenuates Airway Inflammation in Mouse Asthma Model
한국수의병리학회 학술발표논문집
2003 .01
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Expression of HAT1 and HDAC1, 2, 3 in Diffuse Large B-Cell Lymphomas, Peripheral T-Cell Lymphomas, and NK/T-Cell Lymphomas
Journal of Pathology and Translational Medicine
2012 .01
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