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논문 기본 정보

자료유형
학술저널
저자정보
Park, Yooheon (Department of Food and Nutrition, Korea University) Han, Bok Kyung (BK Bio Co. Ltd.) Choi, Hyeon-Son (Department of Food Technology, Seoul Women's University) Hong, Yang Hee (Department of Beauty and Art, Suwon Women's University) Jung, Eun Young (Department of Home Economic Education, Jeonju University) Suh, Hyung Joo (Department of Food and Nutrition, Korea University)
저널정보
한국축산식품학회 한국축산식품학회지 한국축산식품학회지 제35권 제2호
발행연도
2015.1
수록면
164 - 170 (7page)

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The objective of this study was to evaluated the photoprotective effects of porcine placenta extract (PPE) on ultraviolet B (UVB)-induced oxidative stress in human keratinocytes (HaCaT) to evaluate its functional activities as a skin food ingredient. PPE prepared by subcritical water extraction was termed SPE, and subsequently digested by enzymes to prepare E-SPE. Increased intracellular reactive oxygen species (ROS) levels (192.0%) induced by UVB were decreased by SPE and E-SPE. SPE had more effective ROS scavenging activity than E-SPE treatment. UVB treatment increased expression of tissue inhibitor of metalloproteinase 1 (TIMP-1), and this elevated expression was decreased by E-SPE treatment. High-dose treatment with E-SPE (50 and 100 µg/mL) reduced TIMP-1 expression levels of UVB-C (control) to 33.5 and 34.6%, respectively. In contrast, at low SPE doses (1 and 10 µg/mL), the treatment slightly decreased TIMP- 1 expression levels to 73.3% and 71.3% of UVB-C, respectively. In conclusion, the present study demonstrated the protective effect of SPE and E-SPE against UVB damage in keratinocytes via ROS scavenging, down-regulating MMP-2 expression and up-regulating TIMP- 1 expression. This highlights the potential for SPE as an ingredient in the preparation of functional food against photoaging.

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