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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 452 - 457 (6page)
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Lactoferrin is a glycoprotein with various biological effects, with antibacterial activity being one of the first effects reported. This glycoprotein suppresses bacterial growth through bacteriostatic or bactericidal action. It also stimulates the growth of certain kinds of bacteria such as lactic acid bacteria and bifidobacteria. In this study, Asn-Leu-Asn-Arg was selected and chemically synthesized based on the partial sequences of bovine lactoferrin tryptic fragments. Synthetic Asn-Leu-Asn-Arg suppressed the growth of Pseudomonas fluorescens, P. syringae and Escherichia coli. P. fluorescens is a major psychrotrophic bacteria found in raw and pasteurized milk, which decreases milk quality. P. syringae is a harmful infectious bacterium that damages plants. However, synthetic Asn-Leu-Asn-Arg did not inhibit the growth of Lactobacillus acidophilus. It is expected that this synthetic peptide would be the first peptide sequence from the bovine lactoferrin C-lobe that shows antibacterial activity.
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참고문헌 (41)
참고문헌 신청
Baker, E. N. / 2002 / Lactoferrin and transferrin: Functional variations on a common structural framework / Biochem. Cell Biol 80:27~34
Bellamy, W. / 1992 / Antibacterial spectrum of lactoferricin B, a potent bactericidal peptide derived from the N-terminal region of bovine lactoferrin / J. Appl. Bacteriol 73:472~479
Berlutti, F. / 2004 / Both lactoferrin and iron influence aggregation and biofilm formation in Streptococcus mutans / Biometals 17:271~278
Brock, J. H. / 2002 / The physiology of lactoferrin / Biochem. Cell Biol 80:1~6
Bruhn, J. C. / 1985 / Standard Methods for the Examination of Dairy Products / American Public Health Association :265~288
Bellamy, W. / 1992 / Antibacterial spectrum of lactoferricin B, a potent bactericidal peptide derived from the N-terminal region of bovine lactoferrin / J. Appl. Bacteriol 73:472~479
Berlutti, F. / 2004 / Both lactoferrin and iron influence aggregation and biofilm formation in Streptococcus mutans / Biometals 17:271~278
Brock, J. H. / 2002 / The physiology of lactoferrin / Biochem. Cell Biol 80:1~6
Bruhn, J. C. / 1985 / Standard Methods for the Examination of Dairy Products / American Public Health Association :265~288
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