지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Oral administration of soluble antigen can induce peripheral tolerance to the antigen. This study was conducted to evaluate whether gamma-irradiated ovalbumin (OVA) can induce oral tolerance. To investigate this, we administrated intact or irradiated OVA to mice, induced allergic response using intact OVA and alum, then compared humoral and cellular immune responses. Mice treated with gammairradiated OVA had less OVA-specific IgE compared with those who were administered intact OVA. There was no difference in levels of OVA-specific IgG+A+M, IgG1, and IgG2a. Splenocytes of mice administered irradiated OVA showed similar OVA-specific T cell proliferation and secretion of IFN-γ and IL-4. However, there was an increase in IL-2 and a decrease of IL-6 secretion in mice treated with irradiated OVA. These results indicate that gamma-irradiated OVA have similar effects to intact OVA on antigen tolerance.
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등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Abbas, A. K. / 2003 / Cellular and molecular immunology / W.B. Saunders :216~239
Adel-Patient, K. / 2005 / Oral administration of recombinant Lactococcus latis exporessing bovine beta-lactoglobulin partially prevents mice from sensitization / Clin. Exp. Allergy 35:539~546
Asai, K. / 2002 / T cell hyporesponsiveness induced by oral administration of ovalbumin is associated with impaired NFAT nuclear translocation and p27kip 1 degradation / J. Immunol 169:4723~4731
Borish, L. C. / 2003 / Cytokines and chemokines / J. Allergy Clin. Immunol 111:460~475
Byun, M. W. / 2000 / Effects of gamma radiation on the conformation and antigenic properties of a heat-stable major allergen in brown shrimp / J Food Prot 63:940~944
Adel-Patient, K. / 2005 / Oral administration of recombinant Lactococcus latis exporessing bovine beta-lactoglobulin partially prevents mice from sensitization / Clin. Exp. Allergy 35:539~546
Asai, K. / 2002 / T cell hyporesponsiveness induced by oral administration of ovalbumin is associated with impaired NFAT nuclear translocation and p27kip 1 degradation / J. Immunol 169:4723~4731
Borish, L. C. / 2003 / Cytokines and chemokines / J. Allergy Clin. Immunol 111:460~475
Byun, M. W. / 2000 / Effects of gamma radiation on the conformation and antigenic properties of a heat-stable major allergen in brown shrimp / J Food Prot 63:940~944
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