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자료유형
학술저널
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Hong, Eui-Jae (Graduate School of East-West Medical Science, Kyung Hee University) Hong, Seung-Jae (Kohwang Medical Research Institute, Kyung Hee University) Jung, Kyung-Hee (Kohwang Medical Research Institute, Kyung Hee University) Ban, Ju-Yeon (Kohwang Medical Research Institute, Kyung Hee University) Baek, Yong-Hyeon (Department of Acupuncture & Moxibustion, East-West Neo Medical Center, Kyung Hee University) Woo, Hyun-Su (Department of Acupuncture & Moxibustion, East-West Neo Medical Center, Kyung Hee University) Park, Dong-Suk (Department of Acupuncture & Moxibustion, East-West Neo Medical Center, Kyung Hee University)
저널정보
대한독성유전단백체학회 Molecular & cellular toxicology Molecular & cellular toxicology 제4권 제3호
발행연도
2008.1
수록면
224 - 229 (6page)

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Eucommia ulmoides (Duchung) is commonly used for treatment of diabetes in Korean traditional medicine. However, the exact mechanism of its anti-diabetic effect has not yet been fully elucidated. In this study, the effect of E. ulmoides extract on glucose uptake was investigated in L6 rat skeletal muscle cells. E. ulmoides extract stimulated the activity of phosphatidylinositol (PI) 3-kinase that is a major regulatory molecule in glucose uptake pathway. Protein kinase B (PKB) and protein kinase C-${\xi}$ (PKC-${\xi}$), downstream mediators of PI 3-kinase, were also activated by E. ulmoides extract. We assessed the activity of AMP-activated protein kinase (AMPK), another regulatory molecule in glucose uptake pathway. Phosphorylation level of AMPK did not change with treatment of E. ulmoides extract. Phosphorylations of p38 mitogen activated protein kinase (p38 MAPK) and acetyl-CoA carboxylase (ACC), downstream mediators of AMPK, were not significantly different. Taken together, our results suggest that E. ulmoides may stimulate glucose uptake through PI 3-kinase but not AMPK in L6 skeletal muscle cells.

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