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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아내분비학회 Annals of Pediatirc Endocrinology & Metabolism Annals of Pediatirc Endocrinology & Metabolism 제21권 제2호
- 발행연도
- 2016.1
- 수록면
- 61 - 65 (5page)
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초록· 키워드
오류제보하기
AMP-activated protein kinase (AMPK) is a Ser/Thr kinase that has been thought to be an important mediator for exercise-stimulated glucose uptake in skeletal muscle.
Liver kinase B1 (LKB1) is an upstream kinase for AMPK and AMPK-related protein kinases, of which the function in skeletal muscle has not been well documented.
Our group and others have generated mice lacking AMPK activity in skeletal muscle, as well as muscle-specific LKB1 knockout mice. In this review, we discuss the potential role of AMPK and LKB1 in regulating exercise-stimulated glucose uptake in skeletal muscle. We also discuss our recent study, demonstrating the molecular mechanism of obesity-induced development of skeletal muscle insulin resistance.
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등록된 정보가 없습니다.
참고문헌 (45)
참고문헌 신청
DeFronzo RA / 1981 / Synergistic interaction between exercise and insulin on peripheral glucose uptake / J Clin Invest 68:1468~1474
Kennedy JW / 1999 / Acute exercise induces GLUT4translocation in skeletal muscle of normal human subjects and subjects with type 2 diabetes / Diabetes 48:1192~1197
Zierath JR / 1998 / Insulin action in skeletal muscle from patients with NIDDM / Mol Cell Biochem 182:153~160
Hardie DG / 1998 / The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? / Annu Rev Biochem 67:821~855
Hawley SA / 2003 / Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade / J Biol 2:28
Kennedy JW / 1999 / Acute exercise induces GLUT4translocation in skeletal muscle of normal human subjects and subjects with type 2 diabetes / Diabetes 48:1192~1197
Zierath JR / 1998 / Insulin action in skeletal muscle from patients with NIDDM / Mol Cell Biochem 182:153~160
Hardie DG / 1998 / The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? / Annu Rev Biochem 67:821~855
Hawley SA / 2003 / Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade / J Biol 2:28
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