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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.9
- 수록면
- 303 - 310 (8page)
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Selenium and selenoprotein are tightly associated with the protective and antioxidant effects against damage induced by various metal ions in the kidney. Many effects of these kidney damage and stress are mediated by the mitogen-activated protein kinase signaling pathways. To investigate whether selenium treatment and selenoprotein M overexpression would impact on the mitogen-activated protein kinase pathway in the kidney, we detected the phosphorylation level of major components involving p38 kinase, c-jun N-terminal kinase and extracellular signaling-regulated kinase in the transgenic rat overexpressing human selenoprotein M gene. At first, western blot analysis showed that transgenic rats used in this study had the highly expression level of selenoprotein M in the kidney tissue, respectively. The phosphorylation level of p38 kinase was slightly increased in the wild-type rats of selenium-treated group, while did not change in the transgenic rats. Also, the phosphorylation level of c-jun N-terminal kinase was very similar with the change patterns of p38 kinase. Especially, extracellular signaling-regulated kinase was significantly inhibited in the selenium-treatment group. Furthermore, this inhibition rate of extracellular signaling-regulated kinase was stimulated by selenium M overexpression in the transgenic rats. These results suggest that the overexpression of selenoprotein M could effectively influenced the kidney cell proliferation, differentiation and apoptosis through the inhibition of extracellular signaling-regulated kinase in the kidney tissue of transgenic rat.
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재료 및 방법
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고찰
감사의 글
참고문헌
참고문헌 (34)
참고문헌 신청
1. [학술지(정기간행물)] - Balbi, A.P. / 2008 / MAPK and angiotensin II receptor in kidney of newborn rats from losartan-treated dams / Pediatr. Nephrol 23 : 1433 ~ 1444
2. [학술지(정기간행물)] - Birringer, M. / 2002 / Trends in selenium biochemistry / Nat. Prod. Rep 19 : 693 ~ 718
3. [학술지(정기간행물)] - Bruk, R.F. / 1999 / Orphan selenoproteins / BioEssays 21 : 231 ~ 237
4. [학술지(정기간행물)] - Carlson, B.A. / 2004 / Specific excision of the selenocysteine tRNA〔Ser〕Sec (Trsp) gene in mouse liver demonstrates an essetial role of selenoproteins in liver function / J. Biol. Chem 279 : 8011 ~ 8017
5. [학술지(정기간행물)] - Cross, T.G. / 2000 / Serine/threonine protein kinases and apoptosis / Exp. Cell Res 256 : 34 ~ 41
2. [학술지(정기간행물)] - Birringer, M. / 2002 / Trends in selenium biochemistry / Nat. Prod. Rep 19 : 693 ~ 718
3. [학술지(정기간행물)] - Bruk, R.F. / 1999 / Orphan selenoproteins / BioEssays 21 : 231 ~ 237
4. [학술지(정기간행물)] - Carlson, B.A. / 2004 / Specific excision of the selenocysteine tRNA〔Ser〕Sec (Trsp) gene in mouse liver demonstrates an essetial role of selenoproteins in liver function / J. Biol. Chem 279 : 8011 ~ 8017
5. [학술지(정기간행물)] - Cross, T.G. / 2000 / Serine/threonine protein kinases and apoptosis / Exp. Cell Res 256 : 34 ~ 41
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